N-demethyltramadol

Known as: N-desmethyltramadol 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1988-2018
0519882018

Papers overview

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2011
2011
The leaves of Kratom, a medicinal plant in Southeast Asia, have been used as an herbal drug for a long time. At least one of the… (More)
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2011
2011
We investigated whether tramadol or its active metabolite, O-desmethyltramadol, are substrates of the organic cation transporter… (More)
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2009
2009
The study evaluated the pharmacokinetics of tramadol and its major metabolites O-desmethyltramadol (M1), N-desmethyltramadol (M2… (More)
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Highly Cited
2007
Highly Cited
2007
The influence of CYP2D6 genotype and CYP2D6 inhibitors on enantiomeric plasma levels of tramadol and O-desmethyltramadol as well… (More)
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2007
2007
OBJECTIVE Our objective was to evaluate the effect of CYP2D6 phenotype in the enantioselective metabolism of tramadol in Spanish… (More)
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Highly Cited
1997
Highly Cited
1997
Tramadol is an atypical centrally acting analgesic agent with relatively weak opioid receptor affinity in comparison with its… (More)
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1997
1997
Tramadol is a centrally acting, binary analgesic that is neither an opiate-derived nor a nonsteroidal anti-inflammatory drug and… (More)
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Highly Cited
1996
Highly Cited
1996
In in vitro receptor binding and synaptosomal uptake experiments the (+)-enantiomer of tramadol (CAS 148229-78-1) is specific for… (More)
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1993
1993
1. The centrally acting analgesic, tramadol, has low affinity for opioid receptors and therefore presumably other mechanisms of… (More)
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1993
1993
1. Tramadol is a centrally acting analgesic with low opioid receptor affinity and, therefore, presumably additional mechanisms of… (More)
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