Tiludronate

INTRODUCTION The aim of this prospective, randomized, controlled, double-blind study was to evaluate the effects of tiludronate… (More)

Bisphosphonates (BPs) used as inhibitors of bone resorption all contain two phosphonate groups attached to a single carbon atom… (More)

The disposition of tiludronate in mouse, rat, rabbit, dog and monkey has been studied after oral and intravenous doses. Like… (More)

Signaling pathways mediated by tyrosine phosphorylation and dephosphorylation have been reported to be involved in the regulation… (More)

Although bisphosphonates have been shown to be potent inhibitors of osteoclast-mediated bone resorption in vivo and in vitro and… (More)

A double-blind, randomized, placebo-controlled study was performed to evaluate the effect of oral tiludronate therapy in 139… (More)

Immobilization secondary to spinal cord injury is associated with a marked and rapid atrophy of trabecular bone (disuse… (More)

The mechanism of action of tiludronate [(4-chlorophenyl)-thiomethylene bisphosphonate] on osteoclastic bone resorption was… (More)

Tiludronate is a new bisphosphonate whose efficacy has already been reported for the prevention of postmenopausal bone loss. We… (More)

76 healthy women, who had been menopausal for less than 96 months and who had never received any form of treatment to prevent… (More)