Thymitaq

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1996-2003
012319962003

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Highly Cited
2003
Highly Cited
2003
Pemetrexed (ALIMTA, MTA) is a novel thymidylate synthase (TS) inhibitor and has shown activity against colon cancer, mesothelioma… (More)
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2003
2003
BACKGROUND Some anticancer drugs inhibit thymidylate synthase (TS), a key enzyme for thymidine nucleotide biosynthesis. Cells can… (More)
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Review
2001
Review
2001
Zarix is developing Thymitaq (nolatrexed dihydrochloride) for the potential treatment of cancer. It is conducting a phase III… (More)
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1999
1999
Phase I studies of p.o. administered nolatrexed dihydrochloride (AG337, THYMITAQ), a nonclassical thymidylate synthase inhibitor… (More)
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Highly Cited
1999
Highly Cited
1999
Thymidylate synthase (TS), a critical enzyme in the de novo synthesis of thymidylate, is an important target for… (More)
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1999
1999
Summary2-Amino-3,4-dihydro-6-methyl-4-oxo-5-(4-pyridylthio)-quinazoline dihydrochloride (nolatrexed dihydrochloride, Thymitaq… (More)
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1998
1998
Thymidylate synthase plays an essential role in the synthesis of DNA. Recently, several new and specific thymidylate synthase… (More)
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1998
1998
PURPOSE A phase I, multicenter trial of the thymidylate synthase (TS) inhibitor THYMITAQ (nolatrexed dihydrochloride; Agouron… (More)
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1997
1997
Thymidylate synthase (TS) expression has been characterized for a panel of eight human colorectal carcinoma and five human… (More)
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1996
1996
AG337 is the recent non-classical thymidylate synthase inhibitor with promising activity and manageable toxicity in phase I… (More)
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