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Regulatory T cells (Tregs) play an indispensable role in maintaining immunological unresponsiveness to self-antigens and in… Expand CD4+CD25+ regulatory T cells (Treg) are instrumental in the maintenance of immunological tolerance. One critical question is… Expand The thymus represents the major site of the production and generation of T cells expressing αβ-type T-cell antigen receptors. Age… Expand I thank Drs. D. V. Goeddel and P. Golstein for helpful comments on the manuscript. I am grateful to all members of my laboratory… Expand Interferons are cytokines that play a complex and central role in the resistance of mammalian hosts to pathogens. Type I… Expand THE p53 tumour suppressor gene is the most widely mutated gene in human tumorigenesis1,2. p53 encodes a transcriptional… Expand Fas antigen is a cell-surface protein that mediates apoptosis. It is expressed in various tissues including the thymus and has… Expand Corticosteroids, calcium ionophores and anti-CD3 monoclonal antibodies kill mouse thymocytes incubated in vitro. Cell death is… Expand Several soluble factors have recently been associated with the proliferation and differentiation of thymus-derived lymphocytes… Expand A rapid method is described for effectively removing immunoglobulin‐bearing cells from either primed or unprimed mouse spleen and… Expand