Thrombospondin 1

Known as: Thrombospondin-1, TSP-1, TSP1 
An extracellular matrix glycoprotein from platelets and a variety of normal and transformed cells of both mesenchymal and epithelial origin… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1972-2018
05010015019722018

Papers overview

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Highly Cited
2006
Highly Cited
2006
CD36 is necessary for inhibition of some angiogenic responses by the matricellular glycoprotein thrombospondin-1 and is therefore… (More)
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Highly Cited
2006
Highly Cited
2006
Human adenocarcinomas commonly harbor mutations in the KRAS and MYC proto-oncogenes and the TP53 tumor suppressor gene. All three… (More)
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Highly Cited
2002
Highly Cited
2002
Natural inhibitors of angiogenesis are able to block pathological neovascularization without harming the preexisting vasculature… (More)
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Highly Cited
2000
Highly Cited
2000
Thrombospondin-1 (TSP-1) is a naturally occurring inhibitor of angiogenesis that limits vessel density in normal tissues and… (More)
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Highly Cited
1998
Highly Cited
1998
The activity of TGF-beta1 is regulated primarily extracellularly where the secreted latent form must be modified to expose the… (More)
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Highly Cited
1998
Highly Cited
1998
The thrombospondins are a family of extracellular calcium-binding proteins that modulate cellular phenotype. Thrombospondin-1… (More)
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Highly Cited
1998
Highly Cited
1998
Lawrence, 1996). Although named originally for its ability to induce a transformed phenotype in cultured cells 7 its signaling… (More)
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Highly Cited
1997
Highly Cited
1997
Thrombospondin-1 (TSP-1) is a naturally occurring inhibitor of angiogenesis that is able to make normal endothelial cells… (More)
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Highly Cited
1994
Highly Cited
1994
As normal cells progress toward malignancy, they must switch to an angiogenic phenotype to attract the nourishing vasculature… (More)
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Highly Cited
1993
Highly Cited
1993
Thrombospondin-1 (TSP1) is a large modular matrix protein containing three identical disulfide-linked 180-kD chains that inhibits… (More)
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