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Thrombospondin 1

Known as: Thrombospondin-1, TSP-1, TSP1 
An extracellular matrix glycoprotein from platelets and a variety of normal and transformed cells of both mesenchymal and epithelial origin… 
National Institutes of Health

Related topics

Related topics

28 relations
Angiogenesis Inhibitory ProteinAngiogenic ProcessBlood PlateletsCell Adhesion Molecules

Broader (2)

Serine EndopeptidasesThrombospondins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Non-peptidic Thrombospondin-1 Mimics as Fibroblast Growth Factor-2 Inhibitors
Endogenous inhibitors of angiogenesis, such as thrombospondin-1 (TSP-1), are promising sources of therapeutic agents to treat… 
2008
2008
Cell Type-specific Post-transcriptional Regulation of Production of the Potent Antiangiogenic and Proatherogenic Protein Thrombospondin-1 by High Glucose*
Hyperglycemia is an independent risk factor for development of vascular diabetic complications. Vascular dysfunction in diabetics… 
Review
2004
Review
2004
Modulation of Endothelial Cell Survival by an Inhibitor of Angiogenesis Thrombospondin-1: a Dynamic Balance
Angiogenesis is a process of capillary formation from pre-existing blood vessels. It is tightly controlled by the balance between… 
Highly Cited
2003
Highly Cited
2003
Thrombospondin 1--a regulator of adenoma growth and carcinoma progression in the APC(Min/+) mouse model.
Thrombospondin 1 (TSP-1) is a multifunctional extracellular matrix protein that is an endogenous regulator of tumor angiogenesis… 
2003
2003
Aberrant CpG island methylation in neurofibromas and neurofibrosarcomas.
Aberrant methylation of the promoter CpG island of human genes is an alternative gene inactivation mechanism that contributes to… 
Review
2002
Review
2002
Control of von Willebrand factor multimer size and implications for disease.
Highly Cited
2001
Highly Cited
2001
p73 overexpression increases VEGF and reduces thrombospondin-1 production: implications for tumor angiogenesis
Tumor neovascularization is controlled by a balance between positive and negative effectors, whose production can be regulated by… 
1997
1997
In situ localization of thrombospondin‐1 and thrombospondin‐3 transcripts in the avian embryo
Two novel cDNA probes to chicken thrombospondin‐1 (TSP‐1) and TSP‐3 were used to determine by in situ hybridization the origins… 
Highly Cited
1996
Highly Cited
1996
Scatter factor binds to thrombospondin and other extracellular matrix components.
Scatter factor (SF) is an angiogenic growth factor that stimulates motility and invasion of carcinoma cells. SF is present in the… 
1996
1996
Immunohistochemical detection of thrombospondin-1 in formalin-fixed, paraffin-embedded tissue.
Thrombospondin-1 (TSP) is a 450-KD glycoprotein that was initially discovered in the platelet alpha-granule. It now appears that… 
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