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Thrombospondin 1

Known as: Thrombospondin-1, TSP-1, TSP1 
An extracellular matrix glycoprotein from platelets and a variety of normal and transformed cells of both mesenchymal and epithelial origin… 
National Institutes of Health

Related topics

Related topics

28 relations
Angiogenesis Inhibitory ProteinAngiogenic ProcessBlood PlateletsCell Adhesion Molecules

Broader (2)

Serine EndopeptidasesThrombospondins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Non-peptidic Thrombospondin-1 Mimics as Fibroblast Growth Factor-2 Inhibitors
Endogenous inhibitors of angiogenesis, such as thrombospondin-1 (TSP-1), are promising sources of therapeutic agents to treat… 
Highly Cited
2009
Highly Cited
2009
Cytokine secretion by human mesenchymal stem cells cocultured with damaged corneal epithelial cells.
Highly Cited
2006
Highly Cited
2006
Comparative integromics on Angiopoietin family members.
Angiopoietin-1 (ANGPT1), Angiopoietin-4 (ANGPT4), VEGF, FGF2, FGF4, HGF, Ephrin, IL8 and CXCL12 (SFD1) are pro-angiogenic factors… 
Highly Cited
2005
Highly Cited
2005
Autocrine Regulation of T Cell Motility by Calreticulin-Thrombospondin-1 Interaction1
The mechanisms regulating T lymphocyte migration within the extracellular matrix are not understood. We show in this study that… 
Highly Cited
2003
Highly Cited
2003
Promoter hypermethylation of multiple genes in astrocytic gliomas.
Promoter hypermethylation represents a primary mechanism in the inactivation of tumor suppressor genes during tumorigenesis. To… 
Highly Cited
2003
Highly Cited
2003
Thrombospondin 1--a regulator of adenoma growth and carcinoma progression in the APC(Min/+) mouse model.
Thrombospondin 1 (TSP-1) is a multifunctional extracellular matrix protein that is an endogenous regulator of tumor angiogenesis… 
Highly Cited
2001
Highly Cited
2001
p73 overexpression increases VEGF and reduces thrombospondin-1 production: implications for tumor angiogenesis
Tumor neovascularization is controlled by a balance between positive and negative effectors, whose production can be regulated by… 
Highly Cited
2000
Highly Cited
2000
Inhibition of retinal angiogenesis by peptides derived from thrombospondin-1.
PURPOSE Thrombospondin (TSP)1 is a tumor suppressor with activity that is associated with its ability to inhibit… 
1997
1997
In situ localization of thrombospondin‐1 and thrombospondin‐3 transcripts in the avian embryo
Two novel cDNA probes to chicken thrombospondin‐1 (TSP‐1) and TSP‐3 were used to determine by in situ hybridization the origins… 
Highly Cited
1996
Highly Cited
1996
Scatter factor binds to thrombospondin and other extracellular matrix components.
Scatter factor (SF) is an angiogenic growth factor that stimulates motility and invasion of carcinoma cells. SF is present in the… 
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