Thienopyridines

Known as: Thienopyridine Derivatives, Platelet ADP Receptor Antagonist, Derivatives, Thienopyridine 
A class of agents that target at platelet ADP receptor or purinergic receptor P2RY12 with antiplatelet activity.
National Institutes of Health

Papers overview

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Review
2012
Review
2012
Platelet P2Y12 receptor inhibition plays a pivotal role in preventing thrombotic vascular events in patients with ACS and in… (More)
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Highly Cited
2012
Highly Cited
2012
CONTEXT Thienopyridines are among the most widely prescribed medications, but their use can be complicated by the unanticipated… (More)
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Highly Cited
2011
Highly Cited
2011
BACKGROUND Preoperative treatment with thienopyridines is associated with increased postoperative bleeding in cardiac surgery… (More)
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Review
2010
Review
2010
Mark A. Hlatky Stanford University School of Medicine— Professor of Health, Research and Policy and Cardiovascular Medicine… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Thienopyridines are metabolized to active metabolites that irreversibly inhibit the platelet P2Y(12) adenosine… (More)
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Review
2007
Review
2007
Platelets play an important role in atherothrombotic disease, as well as in the pathogenesis of atherosclerosis and in… (More)
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Highly Cited
2006
Highly Cited
2006
The biotransformation of prasugrel to R-138727 (2-[1-2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4-mercapto-3-piperidinylidene… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Combinations of aspirin with thienopyridine derivatives (clopidogrel bisulfate or ticlopidine hydrochloride) and/or… (More)
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Review
2003
Review
2003
The thienopyridines, ticlopidine and clopidogrel, are antiplatelet drugs. They are prodrugs and are metabolised in the liver to… (More)
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Review
1999
Review
1999
The thienopyridines ticlopidine and clopidogrel are inhibitors of platelet function in vivo. Their mode of action has not been… (More)
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