Therapy-Related Myelodysplastic Syndrome

Known as: Therapy Related Myelodysplastic Syndrome, Therapy-Related MDS, t-MDS 
A myelodysplastic syndrome caused by chemotherapy and/or radiotherapy.
National Institutes of Health

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Bone MarrowBone marrow stem cellHematopoietic and Lymphoid CellHematopoietic and Lymphoid Tissue
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Highly Cited
2015
Highly Cited
2015
Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia
Therapy-related acute myeloid leukaemia (t-AML) and therapy-related myelodysplastic syndrome (t-MDS) are well-recognized… (More)
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Highly Cited
2010
Highly Cited
2010
Allogeneic transplantation for therapy-related myelodysplastic syndrome and acute myeloid leukemia.
Therapy-related myelodysplastic syndromes (t-MDSs) and acute myeloid leukemia (t-AML) have a poor prognosis with conventional… (More)
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Highly Cited
2007
Highly Cited
2007
Therapy-related leukemia and myelodysplasia: susceptibility and incidence.
Therapy-related myelodysplastic syndrome/acute myeloid leukemia (t-MDS/AML) is an increasingly recognized treatment complication… (More)
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Highly Cited
2004
Highly Cited
2004
High incidence of somatic mutations in the AML1/RUNX1 gene in myelodysplastic syndrome and low blast percentage myeloid leukemia with myelodysplasia.
A high incidence of somatically acquired point mutations in the AML1/RUNX1 gene has been reported in poorly differentiated acute… (More)
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Highly Cited
2003
Highly Cited
2003
Implications of somatic mutations in the AML1 gene in radiation-associated and therapy-related myelodysplastic syndrome/acute myeloid leukemia.
Somatically acquired point mutations of AML1/RUNX1 gene have been recently identified in rare cases of acute myeloid leukemia… (More)
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Highly Cited
2002
Highly Cited
2002
Pooled analysis of clinical and cytogenetic features in treatment-related and de novo adult acute myeloid leukemia and myelodysplastic syndromes based on a consecutive series of 761 patients analyzed…
To ascertain the frequency of treatment-related acute myeloid leukemias and myelodysplastic syndromes (t-AML/t-MDS) in an… (More)
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Highly Cited
2000
Highly Cited
2000
Allogeneic bone marrow transplantation for therapy-related myelodysplastic syndrome and acute myeloid leukemia: a long-term study of 70 patients-report of the French society of bone marrow…
PURPOSE To identify predictive factors of survival, relapse, and transplantation-related mortality (TRM) among patients with… (More)
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Highly Cited
1996
Highly Cited
1996
Microsatellite instability and p53 mutations in therapy-related leukemia suggest mutator phenotype.
During the last decade the frequency of therapy-related acute leukemia (t-leuk) and myelodysplastic syndrome (t-MDS) has been… (More)
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Highly Cited
1995
Highly Cited
1995
Different genetic pathways in leukemogenesis for patients presenting with therapy-related myelodysplasia and therapy-related acute myeloid leukemia.
Development of myelodysplasia (MDS) with subsequent progression to acute myeloid leukemia (AML) is an example of the multistep… (More)
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Highly Cited
1986
Highly Cited
1986
Clinical and cytogenetic correlations in 63 patients with therapy-related myelodysplastic syndromes and acute nonlymphocytic leukemia: further evidence for characteristic abnormalities of chromosomes…
Clinical, histologic, and cytogenetic features in 63 patients with a therapy-related myelodysplastic syndrome (t-MDS) or acute… (More)
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