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Therapy-Related Acute Myeloid Leukemia

Known as: Treatment Related AML, t-AML, Treatment-Related Acute Myelocytic Leukemia 
An acute myeloid leukemia arising as a result of the mutagenic effect of chemotherapy agents and/or ionizing radiation. (WHO, 2001)
National Institutes of Health

Related topics

Related topics

10 relations
Bone MarrowBone marrow stem cellHematopoietic and Lymphoid CellHematopoietic and Lymphoid Tissue

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2007
Review
2007
Therapy-related myelodysplasia and acute myeloid leukemia following paclitaxel- and carboplatin-based chemotherapy in an ovarian cancer patient: a case report and literature review
Alkylating agents have strong leukemogenic potential. There are a number of recent acute myeloid leukemia (t-AML) cases related… 
Highly Cited
2006
Highly Cited
2006
High-Dose Celecoxib and Metronomic “Low-dose” Cyclophosphamide Is an Effective and Safe Therapy in Patients with Relapsed and Refractory Aggressive Histology Non–Hodgkin's Lymphoma
Purpose: Angiogenesis is increased in aggressive histology non–Hodgkin's lymphoma and may be a target with selective… 
Highly Cited
2006
Highly Cited
2006
Polymorphisms in human homeobox HLX1 and DNA repair RAD51 genes increase the risk of therapy-related acute myeloid leukemia.
Studies of radiation-induced acute myeloid leukemia (AML) in mice suggest that the number of target stem cells is a risk factor… 
Highly Cited
2002
Highly Cited
2002
Rare recurring balanced chromosome abnormalities in therapy‐related myelodysplastic syndromes and acute leukemia: Report from an International Workshop †
Seventy‐seven patients were identified with Rare recurring (excluding 11q23, 21q22, inv(16), and t(15;17)) chromosome… 
2002
2002
Risk of Etoposide-Related Acute Myeloid Leukemia in the Treatment of Epstein-Barr Virus—Associated Hemophagocytic Lymphohistiocytosis
We studied the impact of etoposide on the prognosis of 81 patients (77 of whom were children <15 years old) with Epstein-Barr… 
2000
2000
Novel SH3 protein encoded by the AF3p21 gene is fused to the mixed lineage leukemia protein in a therapy-related leukemia with t(3;11) (p21;q23).
The mixed lineage leukemia (MLL) gene located at chromosome band 11q23 is frequently rearranged in patients with therapy-related… 
1999
1999
Bone marrow transplantation for therapy-induced acute myeloid leukemia in children with previous lymphoid malignancies
Twenty-one children who developed therapy-related acute myeloid leukemia after treatment for acute lymphoblastic leukemia… 
Review
1998
Review
1998
Neuroblastoma and treatment-related myelodysplasia/leukemia: the Memorial Sloan-Kettering experience and a literature review.
PURPOSE To assess treatment-related myelodysplasia/leukemia (t-AML) in neuroblastoma patients by a review of the Memorial Sloan… 
Highly Cited
1997
Highly Cited
1997
Panhandle PCR strategy to amplify MLL genomic breakpoints in treatment-related leukemias.
Panhandle PCR amplifies genomic DNA with known 5' and unknown 3' sequences from a template with an intrastrand loop schematically… 
1997
1997
Identification of complex genomic breakpoint junctions in the t(9;11) MLL-AF9 fusion gene in acute leukemia.
The MLL gene at chromosome 11, band q23, is involved in translocations with as many as 40 different chromosomal bands. Virtually… 
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