Therapy-Related Acute Myeloid Leukemia

Known as: Treatment Related AML, t-AML, Treatment-Related Acute Myelocytic Leukemia 
An acute myeloid leukemia arising as a result of the mutagenic effect of chemotherapy agents and/or ionizing radiation. (WHO, 2001)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1990-2017
051019902017

Papers overview

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2014
2014
Dear Editor, Therapy-related myeloid neoplasms (t-MNs) are a unique clinical entity occurring as late complication of… (More)
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Highly Cited
2011
Highly Cited
2011
To study the characteristics and clinical impact of therapy-related acute myeloid leukemia (t-AML). 200 patients (7.0%) had t-AML… (More)
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2008
2008
The p53 tumor suppressor directs the cellular response to many mechanistically distinct DNA-damaging agents and is selected… (More)
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2006
2006
We report the results of 65 patients with treatment-related myelodysplastic syndrome (MDS)/acute myelogenous leukemia (AML) who… (More)
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Highly Cited
2004
Highly Cited
2004
The aim of this study was to compare the pattern of karyotype abnormalities of therapy-related acute myeloid leukemia (t-AML) (n… (More)
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Highly Cited
2002
Highly Cited
2002
One of the most serious consequences of cytotoxic cancer therapy is the development of therapy-related acute myeloid leukemia (t… (More)
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Highly Cited
2001
Highly Cited
2001
Glutathione S-transferases (GSTs) detoxify potentially mutagenic and toxic DNA-reactive electrophiles, including metabolites of… (More)
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Highly Cited
1999
Highly Cited
1999
NAD(P)H:quinone oxidoreductase (NQO1) converts benzene-derived quinones to less toxic hydroquinones and has been implicated in… (More)
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Highly Cited
1999
Highly Cited
1999
MLL (ALL1, Htrx, HRX), which is located on chromosome band 11q23, frequently is rearranged in patients with therapy-related acute… (More)
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Highly Cited
1995
Highly Cited
1995
Development of myelodysplasia (MDS) with subsequent progression to acute myeloid leukemia (AML) is an example of the multistep… (More)
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