Therapy-Related Acute Myeloid Leukemia

Known as: Treatment Related AML, t-AML, Treatment-Related Acute Myelocytic Leukemia 
An acute myeloid leukemia arising as a result of the mutagenic effect of chemotherapy agents and/or ionizing radiation. (WHO, 2001)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1990-2017
051019902017

Related topics

Related topics

10 relations
Bone MarrowBone marrow stem cellHematopoietic and Lymphoid CellHematopoietic and Lymphoid Tissue
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Related mentions per year

Related mentions per year

1936-2019
19401960198020002020
Therapy-Related Acute Myeloid Leukemia
cancer cell
Bone Marrow
Neoplastic Cell
Leukemic Cell
Bone marrow stem cell

Papers overview

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2014
2014
Preexisting TP53 mutation in therapy-related acute myeloid leukemia
Dear Editor, Therapy-related myeloid neoplasms (t-MNs) are a unique clinical entity occurring as late complication of… (More)
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Highly Cited
2011
Highly Cited
2011
The impact of therapy-related acute myeloid leukemia (AML) on outcome in 2853 adult patients with newly diagnosed AML.
To study the characteristics and clinical impact of therapy-related acute myeloid leukemia (t-AML). 200 patients (7.0%) had t-AML… (More)
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2008
2008
MDM2 SNP309 and TP53 Arg72Pro interact to alter therapy-related acute myeloid leukemia susceptibility.
The p53 tumor suppressor directs the cellular response to many mechanistically distinct DNA-damaging agents and is selected… (More)
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2006
2006
Autologous stem cell transplantation for therapy-related acute myeloid leukemia and myelodysplastic syndrome
We report the results of 65 patients with treatment-related myelodysplastic syndrome (MDS)/acute myelogenous leukemia (AML) who… (More)
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Highly Cited
2004
Highly Cited
2004
Karyotype is an independent prognostic parameter in therapy-related acute myeloid leukemia (t-AML): an analysis of 93 patients with t-AML in comparison to 1091 patients with de novo AML
The aim of this study was to compare the pattern of karyotype abnormalities of therapy-related acute myeloid leukemia (t-AML) (n… (More)
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Highly Cited
2002
Highly Cited
2002
Expression profiling of CD34+ hematopoietic stem/ progenitor cells reveals distinct subtypes of therapy-related acute myeloid leukemia.
One of the most serious consequences of cytotoxic cancer therapy is the development of therapy-related acute myeloid leukemia (t… (More)
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Highly Cited
2001
Highly Cited
2001
Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapy-induced leukemia.
Glutathione S-transferases (GSTs) detoxify potentially mutagenic and toxic DNA-reactive electrophiles, including metabolites of… (More)
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Highly Cited
1999
Highly Cited
1999
Prevalence of the inactivating 609C-->T polymorphism in the NAD(P)H:quinone oxidoreductase (NQO1) gene in patients with primary and therapy-related myeloid leukemia.
NAD(P)H:quinone oxidoreductase (NQO1) converts benzene-derived quinones to less toxic hydroquinones and has been implicated in… (More)
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Highly Cited
1999
Highly Cited
1999
MSF (MLL septin-like fusion), a fusion partner gene of MLL, in a therapy-related acute myeloid leukemia with a t(11;17)(q23;q25).
MLL (ALL1, Htrx, HRX), which is located on chromosome band 11q23, frequently is rearranged in patients with therapy-related acute… (More)
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Highly Cited
1995
Highly Cited
1995
Different genetic pathways in leukemogenesis for patients presenting with therapy-related myelodysplasia and therapy-related acute myeloid leukemia.
Development of myelodysplasia (MDS) with subsequent progression to acute myeloid leukemia (AML) is an example of the multistep… (More)
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