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Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia
Familial platelet disorder with predisposition to acute myelogenous leukaemia (FPD/AML, MIM 601399) is an autosomal dominant disorder characterized by qualitative and quantitative platelet defects,Expand
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Secondary leukemias induced by topoisomerase-targeted drugs.
  • C. Felix
  • Biology, Medicine
  • Biochimica et biophysica acta
  • 1 October 1998
The major established cause of acute myeloid leukemia (AML) in the young is cancer chemotherapy. There are two forms of treatment-related AML (t-AML). Each form has a de novo counterpart. AlkylatingExpand
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Association of CYP3A4 genotype with treatment-related leukemia.
Epipodophyllotoxins are associated with leukemias characterized by translocations of the MLL gene at chromosome band 11q23 and other translocations. Cytochrome P450 (CYP) 3A metabolizesExpand
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The molecular basis of leukemia.
Major strides have been made in our understanding of the molecular basis of adult and pediatric leukemias. More than one hundred disease alleles have been identified and characterized in cell cultureExpand
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DNA topoisomerase II in therapy-related acute promyelocytic leukemia.
BACKGROUND Chromosomal translocations leading to chimeric oncoproteins are important in leukemogenesis, but how they form is unclear. We studied acute promyelocytic leukemia (APL) with the t(15;17)Expand
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Topoisomerase II and leukemia
Type II topoisomerases are essential enzymes that modulate DNA under‐ and overwinding, knotting, and tangling. Beyond their critical physiological functions, these enzymes are the targets for some ofExpand
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The t(11;20)(p15;q11) chromosomal translocation associated with therapy-related myelodysplastic syndrome results in an NUP98-TOP1 fusion.
The NUP98 gene is involved in 3 distinct chromosomal rearrangements, t(7;11)(p15;p15), t(2;11)(q31;p15), and inv(11)(p15q22); all of these NUP98 rearrangements have been identified in the malignantExpand
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Maternal Diet and Infant Leukemia: The DNA Topoisomerase II Inhibitor Hypothesis: A Report from the Children's Oncology Group
Background: The MLL 11q23 translocation arises in utero and is present in 75% of infant leukemias. That MLL+ acute myeloid leukemia (AML) can arise following chemotherapy with DNA topoisomerase IIExpand
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Topoisomerase II and the etiology of chromosomal translocations.
Acute leukemias with balanced chromosomal translocations, protean morphologic and immunophenotypic presentations but generally shorter latency and absence of myelodysplasia are recognized as aExpand
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Leukemias related to treatment with DNA topoisomerase II inhibitors.
  • C. Felix
  • Biology, Medicine
  • Medical and pediatric oncology
  • 1 May 2001
The epipodophyllotoxins etoposide and teniposide and other DNA topoisomerase II inhibitors including anthracyclines and dactinomycin are highly efficacious anticancer drugs. All are associated with aExpand
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