Therapeutic agent (substance)

Known as: therapeutic agent, therapeutic agents 
 
National Institutes of Health

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3 relations
MetabolismTherapeutic agentdrug metabolism

Papers overview

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Review
2017
Review
2017
Roles of tau protein in health and disease
Tau is well established as a microtubule-associated protein in neurons. However, under pathological conditions, aberrant assembly… (More)
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Review
2017
Review
2017
The ascending pathophysiology of cholestatic liver disease.
In this review we develop the argument that cholestatic liver diseases, particularly primary biliary cholangitis and primary… (More)
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Highly Cited
2014
Highly Cited
2014
Clinical trial evidence supporting FDA approval of novel therapeutic agents, 2005-2012.
IMPORTANCE Many patients and physicians assume that the safety and effectiveness of newly approved therapeutic agents is well… (More)
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Highly Cited
2011
Highly Cited
2011
Differential Role of Anandamide and 2-Arachidonoylglycerol in Memory and Anxiety-like Responses
BACKGROUND Cannabinoid agonists are potential therapeutic agents because of their antinociceptive and anxiolytic-like effects… (More)
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Review
2008
Review
2008
Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease
Intranasal delivery provides a practical, non-invasive method of bypassing the blood-brain barrier (BBB) to deliver therapeutic… (More)
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Highly Cited
2007
Highly Cited
2007
Repeated administration of vanilloid receptor TRPV1 antagonists attenuates hyperthermia elicited by TRPV1 blockade.
Capsaicin, the active ingredient in some pain-relieving creams, is an agonist of a nonselective cation channel known as the… (More)
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Highly Cited
2007
Highly Cited
2007
Real-time image-guided direct convective perfusion of intrinsic brainstem lesions
J. Neurosurg. / Volume 107 / July, 2007 ANY intrinsic diseases of the brainstem result in complications or death because there… (More)
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2007
2007
Real-time image-guided direct convective perfusion of intrinsic brainstem lesions. Technical note.
Recent preclinical studies have demonstrated that convection-enhanced delivery (CED) can be used to perfuse the brain and… (More)
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Review
2006
Review
2006
Tight junction modulation and its relationship to drug delivery.
In order for therapeutic agents to exert their pharmacological effects, they have to cross the biological membranes into the… (More)
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Highly Cited
2005
Highly Cited
2005
Reflux-free cannula for convection-enhanced high-speed delivery of therapeutic agents.
OBJECT Clinical application of the convection-enhanced delivery (CED) technique is currently limited by low infusion speed and… (More)
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