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Therapeutic Targets Database
Known as:
TTD
, Therapeutic target
Therapeutic Target Database (TTD) is a database provided by Bioinformatics and Drug Design Group in National University of Singapore, which provides…
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2 relations
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DrugBank
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Enhanced Expression of EHMT 2 Is Involved in the Proliferation of Cancer Cells through Negative Regulation of SIAH 11 , 2
Hyun-soo Cho
,
J. Kelly
,
+9 authors
Ryuji Hamamoto
2014
Corpus ID: 108287472
EHMT2 is a histone lysine methyltransferase localized in euchromatin regions and acting as a corepressor for specific…
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Highly Cited
2011
Highly Cited
2011
Integrated Systems and Technologies : Mathematical Oncology p 38 g Promotes Breast Cancer Cell Motility and Metastasis through Regulation of RhoC GTPase , Cytoskeletal Architecture , and a Novel…
D. Rosenthal
,
H. Iyer
,
+7 authors
S. Merajver
2011
Corpus ID: 15005343
Understanding the molecular alterations that confer cancer cells with motile, metastatic properties is needed to improve patient…
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Review
2010
Review
2010
FLT 3 as a therapeutic target in AML : still challenging after all these years
T. Kindler
,
D. Lipka
,
T. Fischer
2010
Corpus ID: 6448189
Mutations within the FMS-like tyrosine kinase 3 (FLT3) gene on chromosome 13q12 have been detected in up to 35% of acute myeloid…
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2010
2010
Cancer esearch or and Stem Cell Biology or-Initiating Function of Nucleostemin-Enriched R mary Tumor Cells in
Lingjun Meng
,
Yi Li
,
R. Y. Tsai
2010
Corpus ID: 207677661
nloaded leostemin (NS) is highly expressed in normal stem cells and tumors and is upregulated by estradiol in breast cancer cells…
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2007
2007
IRE 1 Signaling Is Essential for Ischemia-Induced Vascular Endothelial Growth Factor-A Expression and Contributes to Angiogenesis and Tumor Growth In vivo
Benjamin Drogat
,
P. Auguste
,
+7 authors
M. Moenner
2007
Corpus ID: 20372667
In solid tumors, cancer cells subjected to ischemic conditions trigger distinct signaling pathways contributing to angiogenic…
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Review
2007
Review
2007
Telomerase and telomere dynamics in ageing and cancer: current status and future directions.
F. Camarena
,
G. Serral
,
F. S. Santaló
2007
Corpus ID: 38545843
This review will focus on the clinical utilities of telomerase for human cancer diagnosis and progno- sis. Much attention has…
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2005
2005
Fusion of EML 1 to ABL 1 in T-cell acute lymphoblastic leukemia with cryptic t ( 9 ; 14 ) ( q 34 ; q 32 )
K. De Keersmaecker
,
C. Graux
,
+8 authors
J. Cools
2005
Corpus ID: 1945808
The BCR-ABL1 fusion kinase is frequently associated with chronic myeloid leukemia and B-cell acute lymphoblastic leukemia but is…
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2005
2005
Atomic force microscopy reveals the stoichiometry and subunit arrangement of 5-HT 3 receptors
N. Barrera
,
P. Herbert
,
R. Henderson
,
I. Martin
,
J. Edwardson
2005
Corpus ID: 26812939
The 5-HT3 receptor is a cation-selective ligand-gated ion channel of the Cys-loop superfamily. The receptor is an important…
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Highly Cited
2004
Highly Cited
2004
Costimulatory B 7-H 1 in renal cell carcinoma patients : Indicator of tumor aggressiveness and potential therapeutic target
R. Thompson
,
Michael D. Gillett
,
+12 authors
E. Kwon
2004
Corpus ID: 30835163
Expression of B7-H1, a costimulating glycoprotein in the B7 family, is normally restricted to macrophage-lineage cells, providing…
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Highly Cited
1991
Highly Cited
1991
The complexities of AIDS : an assessment of the HIV protease as a therapeutic target
A. Tomasselli
,
W. Howe
,
T. Sawyer
,
A. Wlodawer
,
R. Heinrikson
1991
Corpus ID: 89374925
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