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Therapeutic Targets Database

Known as: TTD, Therapeutic target 
Therapeutic Target Database (TTD) is a database provided by Bioinformatics and Drug Design Group in National University of Singapore, which provides… 
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Papers overview

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2014
2014
Enhanced Expression of EHMT 2 Is Involved in the Proliferation of Cancer Cells through Negative Regulation of SIAH 11 , 2
EHMT2 is a histone lysine methyltransferase localized in euchromatin regions and acting as a corepressor for specific… 
Highly Cited
2011
Highly Cited
2011
Integrated Systems and Technologies : Mathematical Oncology p 38 g Promotes Breast Cancer Cell Motility and Metastasis through Regulation of RhoC GTPase , Cytoskeletal Architecture , and a Novel…
Understanding the molecular alterations that confer cancer cells with motile, metastatic properties is needed to improve patient… 
Review
2010
Review
2010
FLT 3 as a therapeutic target in AML : still challenging after all these years
Mutations within the FMS-like tyrosine kinase 3 (FLT3) gene on chromosome 13q12 have been detected in up to 35% of acute myeloid… 
2010
2010
Cancer esearch or and Stem Cell Biology or-Initiating Function of Nucleostemin-Enriched R mary Tumor Cells in
nloaded leostemin (NS) is highly expressed in normal stem cells and tumors and is upregulated by estradiol in breast cancer cells… 
2007
2007
IRE 1 Signaling Is Essential for Ischemia-Induced Vascular Endothelial Growth Factor-A Expression and Contributes to Angiogenesis and Tumor Growth In vivo
In solid tumors, cancer cells subjected to ischemic conditions trigger distinct signaling pathways contributing to angiogenic… 
Review
2007
Review
2007
Telomerase and telomere dynamics in ageing and cancer: current status and future directions.
This review will focus on the clinical utilities of telomerase for human cancer diagnosis and progno- sis. Much attention has… 
2005
2005
Fusion of EML 1 to ABL 1 in T-cell acute lymphoblastic leukemia with cryptic t ( 9 ; 14 ) ( q 34 ; q 32 )
The BCR-ABL1 fusion kinase is frequently associated with chronic myeloid leukemia and B-cell acute lymphoblastic leukemia but is… 
2005
2005
Atomic force microscopy reveals the stoichiometry and subunit arrangement of 5-HT 3 receptors
The 5-HT3 receptor is a cation-selective ligand-gated ion channel of the Cys-loop superfamily. The receptor is an important… 
Highly Cited
2004
Highly Cited
2004
Costimulatory B 7-H 1 in renal cell carcinoma patients : Indicator of tumor aggressiveness and potential therapeutic target
Expression of B7-H1, a costimulating glycoprotein in the B7 family, is normally restricted to macrophage-lineage cells, providing… 
Highly Cited
1991
Highly Cited
1991
The complexities of AIDS : an assessment of the HIV protease as a therapeutic target
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