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Structural Basis for the Substrate Specificity of Tobacco Etch Virus Protease*
Because of its stringent sequence specificity, the 3C-type protease from tobacco etch virus (TEV) is frequently used to remove affinity tags from recombinant proteins. It is unclear, however, exactlyExpand
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Inhibitors of HIV-1 protease: a major success of structure-assisted drug design.
Retroviral protease (PR) from the human immunodeficiency virus type 1 (HIV-1) was identified over a decade ago as a potential target for structure-based drug design. This effort was very successful.Expand
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Catalytic triads and their relatives.
Interactions among the residues in the serine protease Asp-His-Ser catalytic triad, in the special environment of the enzyme-substrate complex, activate the nucleophilic potential of the seryl OExpand
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Crystal structure of A. fulgidus Rio2 defines a new family of serine protein kinases.
The RIO family of atypical serine/threonine kinases contains two subfamilies, Rio1 and Rio2, highly conserved from archaea to man. Both RIO proteins from Saccharomyces cerevisiae catalyze serineExpand
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High-resolution structure of the catalytic domain of avian sarcoma virus integrase.
Retroviral integrase (IN) functions to insert retroviral DNA into the host cell chromosome in a highly coordinated manner. IN catalyzes two biochemically separable reactions: processing of the viralExpand
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Protein crystallography for non‐crystallographers, or how to get the best (but not more) from published macromolecular structures
The number of macromolecular structures deposited in the Protein Data Bank now exceeds 45 000, with the vast majority determined using crystallographic methods. Thousands of studies describing suchExpand
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Filamentous phage infection: crystal structure of g3p in complex with its coreceptor, the C-terminal domain of TolA.
BACKGROUND Infection of male Escherichia coli cells by filamentous Ff bacteriophages (M13, fd, and f1) involves interaction of the phage minor coat gene 3 protein (g3p) with the bacterial F pilusExpand
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Crystal Structure of the Dimeric C-terminal Domain of TonB Reveals a Novel Fold*
The TonB-dependent complex of Gram-negative bacteria couples the inner membrane proton motive force to the active transport of iron·siderophore and vitamin B12 across the outer membrane. TheExpand
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New protein fold revealed by a 2.3-Å resolution crystal structure of nerve growth factor
NERVE growth factor (NGF)1is a member of an expanding family of neurotrophic factors (including brain-derived neurotrophic factor2 and the neurotrophins3,4) that control the development and survivalExpand
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Crystal structure of rabbit muscle creatine kinase 1
The crystal structure of rabbit muscle creatine kinase, solved at 2.35 Å resolution by X‐ray diffraction methods, clearly identified the active site with bound sulfates surrounded by a constellationExpand
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