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Tetraspanins

Known as: Tetraspanins [Chemical/Ingredient] 
A large superfamily of cell surface membrane proteins characterized by their four transmembrane domains. They play a role in a variety of processes… 
National Institutes of Health

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In BloodMARVEL Domain-Containing ProteinsProcess of secretionagonists

Narrower (7)

PHEMX protein, humanTSPAN1 protein, humanTSPAN10 protein, humanTSPAN31 protein, human

Papers overview

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Review
2018
Review
2018
The Role of Exosomal Tetraspanins and Proteases in Tumor Progression
Major (CD9, CD63, CD81) and other (CD82, CD151, Tspan8) exosomal tetraspanins interact with various proteins and form functional… 
2013
2013
Roles for HB‐EGF and CD9 in multiple sclerosis
Early events in multiple sclerosis (MS) lesion formation are loss of blood–brain barrier (BBB) integrity, immune cell trafficking… 
Review
2011
Review
2011
Membrane proteases and tetraspanins.
TEMs (tetraspanin-enriched microdomains) are specialized platforms in the plasma membrane that include adhesion receptors and… 
Highly Cited
2007
Highly Cited
2007
Overexpression of tetraspanins affects multiple myeloma cell survival and invasive potential
Cellular interactions with microenviron‐mental components are critical in multiple myeloma (MM) and impede effective disease… 
Review
2007
Review
2007
Tetraspanins-structural and signalling scaffolds that regulate platelet function.
There are several tetraspanins present in platelets including CD9, CD151, TSSC6, and CD63. Recent studies in knockout mouse… 
2007
2007
Xenopus Tetraspanin-1 regulates gastrulation movements and neural differentiation in the early Xenopus embryo.
The tetraspanin family of four-pass transmembrane proteins has been implicated in fundamental biological processes, including… 
2006
2006
CDw78 Defines MHC Class II-Peptide Complexes That Require Ii Chain-Dependent Lysosomal Trafficking, Not Localization to a Specific Tetraspanin Membrane Microdomain1
MHC class II molecules (MHC-II) associate with detergent-resistant membrane microdomains, termed lipid rafts, which affects the… 
2006
2006
Role of integrins, tetraspanins, and ADAM proteins during the development of apoptotic bodies by spermatogenic cells
We have previously reported that Sertoli cell geometric changes induced by a Fas (CD95) agonist or by restricting Sertoli cell… 
Highly Cited
2003
Highly Cited
2003
A Functionally Relevant Conformational Epitope on the CD9 Tetraspanin Depends on the Association with Activated β1Integrin*
Tetraspanins associate on the cell membrane with several transmembrane proteins, including members of the integrin superfamily… 
Highly Cited
1998
Highly Cited
1998
Signaling through the tetraspanin CD82 triggers its association with the cytoskeleton leading to sustained morphological changes and T cell activation
In this report, we provide new evidence of a crosstalk between T cell activation and adhesion processes through a functional… 
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