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PGE2 differentially regulates monocyte-derived dendritic cell cytokine responses depending on receptor usage (EP2/EP4).
Dendritic cells (DCs) are central players in coordinating immune responses, both innate and adaptive. While the role of lipid mediators in the immune response has been the subject of manyExpand
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Recent Progress in Prostaglandin F2α Ethanolamide (Prostamide F2α) Research and Therapeutics
Prostamide (prostaglandin ethanolamide) research emerged from two distinct lines of research: 1) the unique pharmacology of the antiglaucoma drug bimatoprost and 2) the discovery that endocannabinoidExpand
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Anandamide-derived Prostamide F2α Negatively Regulates Adipogenesis
Background: Adipogenesis is the process by which adipocytes are formed to maintain or expand fat depots. Results: Prostaglandin F2α ethanolamide (PGF2αEA) is produced from anandamide in preadipocytesExpand
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Prostaglandin E2-Glyceryl Ester: In Vivo Evidence for a Distinct Pharmacological Identity from Intraocular Pressure Studies
Prostaglandin E2 (PGE2)-2-glyceryl ester is a cyclo-oxygenase 2 product of the endocannabinoid 2-arachidonyl glycerol. It is claimed as pharmacologically novel, but this is complicated by rapid andExpand
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Androgenetic alopecia: combing the hair follicle signaling pathways for new therapeutic targets and more effective treatment options
ABSTRACT Introduction: In the past 30 years, only two drugs have received FDA approval for the treatment of androgenetic alopecia reflecting a lack of success in unraveling novel targets forExpand
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A Prostacyclin Analog, Cicaprost, Exhibits Potent Anti-Inflammatory Activity in Human Primary Immune Cells and a Uveitis Model.
PURPOSE To investigate the therapeutic potential of a prostacyclin (IP) receptor agonist for ocular inflammation and the effect on immune cells. METHODS The anti-inflammatory activities ofExpand
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Mechanistic insight into the activity of a sulfone compound dapsone on Propionibacterium (Newly Reclassified as Cutibacterium) Acnes‐mediated cytokine production
Acne remains as the most common skin disease in the United States even despite multiple approved topical and systemic medications available. These treatments available over the counter and byExpand
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In vivo studies validating multitargeting of prostanoid receptors for achieving superior anti‐inflammatory effects
The purpose of these studies was to test the hypothesis that a selected polypharmacological approach for treating the prostanoid‐mediated component of inflammatory diseases would produce aExpand
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In Vivo Choroidal Neovascularization and Macrophage Studies Provide Further Evidence for a Broad Role of Prostacyclin in Angiogenesis.
PURPOSE The purpose of these studies was (1) to investigate the ability of human M1 phenotype macrophages to secrete vascular endothelial growth factor (VEGF) and the influence of prostacyclinExpand
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