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Tetraphenyl Chlorin Disulfonate

Known as: Disulfonated Tetraphenylchlorin, TPCS2a 
A meso-tetraphenylchlorin substituted by two adjacent sulfonated groups with potential photosensitizing activity. Upon administration, tetraphenyl… Expand
National Institutes of Health

Papers overview

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2018
2018
Enhanced targeting of triple-negative breast carcinoma and malignant melanoma by photochemical internalization of CSPG4-targeting immunotoxins.
Triple-negative breast cancer (TNBC) and malignant melanoma are highly aggressive cancers that widely express the cell surface… Expand
2017
2017
Development of resistance to photodynamic therapy (PDT) in human breast cancer cells is photosensitizer‐dependent: Possible mechanisms and approaches for overcoming PDT‐resistance
ABSTRACT Here we report on the induction of resistance to photodynamic therapy (PDT) in the ABCG2‐high human breast cancer cell… Expand
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Highly Cited
2016
Highly Cited
2016
Disulfonated tetraphenyl chlorin (TPCS2a)-induced photochemical internalisation of bleomycin in patients with solid malignancies: a phase 1, dose-escalation, first-in-man trial.
BACKGROUND Photochemical internalisation, a novel minimally invasive treatment, has shown promising preclinical results in… Expand
Highly Cited
2015
Highly Cited
2015
Light-controlled endosomal escape of the novel CD133-targeting immunotoxin AC133-saporin by photochemical internalization - A minimally invasive cancer stem cell-targeting strategy.
The cancer stem cell (CSC) marker CD133 is an attractive target to improve antitumor therapy. We have used photochemical… Expand
2014
2014
Light-triggered, efficient cytosolic release of IM7-saporin targeting the putative cancer stem cell marker CD44 by photochemical internalization.
We have used the site specific and light-depended drug delivery method photochemical internalization (PCI) to release an… Expand
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2014
2014
Controlled disulfonated poly(arylene ether sulfone) multiblock copolymers for direct methanol fuel cells.
Structure-property-performance relationships of disulfonated poly(arylene ether sulfone) multiblock copolymer membranes were… Expand
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2014
2014
Photochemical internalization augments tumor vascular cytotoxicity and specificity of VEGF(121)/rGel fusion toxin.
Vascular targeting for cancer is increasingly recognized as a therapeutic strategy although the lack of objective responses and… Expand
2013
2013
Photochemical internalization of CD133-targeting immunotoxins efficiently depletes sarcoma cells with stem-like properties and reduces tumorigenicity.
BACKGROUND The normal stem cell marker CD133 is also a putative marker of cancer stem cells (CSCs) in different types of cancers… Expand
2013
2013
Photochemical internalization (PCI) of immunotoxins targeting CD133 is specific and highly potent at femtomolar levels in cells with cancer stem cell properties.
CD133 is a putative cancer stem cell (CSC) marker for a number of different cancers and is suggested to be a therapeutic target… Expand
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Highly Cited
2011
Highly Cited
2011
Disulfonated tetraphenyl chlorin (TPCS2a), a novel photosensitizer developed for clinical utilization of photochemical internalization.
Photochemical internalisation (PCI) is a novel technology for release of endocytosed macromolecules into the cytosol. The… Expand
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