FAQ

Tetraphenyl Chlorin Disulfonate

Known as: Disulfonated Tetraphenylchlorin, TPCS2a 
A meso-tetraphenylchlorin substituted by two adjacent sulfonated groups with potential photosensitizing activity. Upon administration, tetraphenyl… (More)

Topic mentions per year

Topic mentions per year

2010-2017
024620102017

Papers overview

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2016
2016
Disulfonated tetraphenyl chlorin (TPCS2a)-induced photochemical internalisation of bleomycin in patients with solid malignancies: a phase 1, dose-escalation, first-in-man trial.
BACKGROUND Photochemical internalisation, a novel minimally invasive treatment, has shown promising preclinical results in… (More)
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2015
2015
Light-controlled endosomal escape of the novel CD133-targeting immunotoxin AC133-saporin by photochemical internalization - A minimally invasive cancer stem cell-targeting strategy.
The cancer stem cell (CSC) marker CD133 is an attractive target to improve antitumor therapy. We have used photochemical… (More)
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2015
2015
Studies of the photosensitizer disulfonated meso-tetraphenyl chlorin in an orthotopic rat bladder tumor model.
BACKGROUND Photochemical internalization (PCI) is a novel technology for the release of a therapeutic molecule from endocytic… (More)
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2014
2014
Light-triggered, efficient cytosolic release of IM7-saporin targeting the putative cancer stem cell marker CD44 by photochemical internalization.
We have used the site specific and light-depended drug delivery method photochemical internalization (PCI) to release an… (More)
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2014
2014
Photochemical internalization augments tumor vascular cytotoxicity and specificity of VEGF(121)/rGel fusion toxin.
Vascular targeting for cancer is increasingly recognized as a therapeutic strategy although the lack of objective responses and… (More)
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2013
2013
Photochemical internalization of CD133-targeting immunotoxins efficiently depletes sarcoma cells with stem-like properties and reduces tumorigenicity.
BACKGROUND The normal stem cell marker CD133 is also a putative marker of cancer stem cells (CSCs) in different types of cancers… (More)
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2013
2013
Impact of Photosensitizers Activation on Intracellular Trafficking and Viscosity
The intracellular microenvironment is essential for the efficiency of photo-induced therapies, as short-lived reactive oxygen… (More)
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2011
2011
Disulfonated tetraphenyl chlorin (TPCS2a), a novel photosensitizer developed for clinical utilization of photochemical internalization.
Photochemical internalisation (PCI) is a novel technology for release of endocytosed macromolecules into the cytosol. The… (More)
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2011
2011
Evaluation of physicochemical properties and aggregation of the photosensitizers TPCS2a and TPPS2a in aqueous media.
Physicochemical properties of the novel photosensitizer meso-tetraphenyl chlorin disulphonate (TPCS2a) and the chemically related… (More)
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2010
2010
Physicochemical characterization of the photosensitizers TPCS2a and TPPS2a 1. Spectroscopic evaluation of drug--solvent interactions.
The spectroscopic properties of the patented photosensitizer meso-tetraphenyl chlorin disulphonate (TPCS2a), intended for use in… (More)
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