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Tetraphenyl Chlorin Disulfonate

Known as: Disulfonated Tetraphenylchlorin, TPCS2a 
A meso-tetraphenylchlorin substituted by two adjacent sulfonated groups with potential photosensitizing activity. Upon administration, tetraphenyl… 
National Institutes of Health

Papers overview

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2017
2017
Development of resistance to photodynamic therapy (PDT) in human breast cancer cells is photosensitizer‐dependent: Possible mechanisms and approaches for overcoming PDT‐resistance
Highly Cited
2016
Highly Cited
2016
Disulfonated tetraphenyl chlorin (TPCS2a)-induced photochemical internalisation of bleomycin in patients with solid malignancies: a phase 1, dose-escalation, first-in-man trial.
Highly Cited
2015
Highly Cited
2015
Combining magnetic nanoparticles with cell derived microvesicles for drug loading and targeting.
Highly Cited
2015
Highly Cited
2015
Light-controlled endosomal escape of the novel CD133-targeting immunotoxin AC133-saporin by photochemical internalization - A minimally invasive cancer stem cell-targeting strategy.
2014
2014
Light-triggered, efficient cytosolic release of IM7-saporin targeting the putative cancer stem cell marker CD44 by photochemical internalization.
We have used the site specific and light-depended drug delivery method photochemical internalization (PCI) to release an… 
2014
2014
Controlled disulfonated poly(arylene ether sulfone) multiblock copolymers for direct methanol fuel cells.
Structure-property-performance relationships of disulfonated poly(arylene ether sulfone) multiblock copolymer membranes were… 
2014
2014
Photochemical internalization augments tumor vascular cytotoxicity and specificity of VEGF(121)/rGel fusion toxin.
2013
2013
Photochemical internalization (PCI) of immunotoxins targeting CD133 is specific and highly potent at femtomolar levels in cells with cancer stem cell properties.
2013
2013
Photochemical internalization of CD133-targeting immunotoxins efficiently depletes sarcoma cells with stem-like properties and reduces tumorigenicity.
Highly Cited
2011
Highly Cited
2011
Disulfonated tetraphenyl chlorin (TPCS2a), a novel photosensitizer developed for clinical utilization of photochemical internalization.
Photochemical internalisation (PCI) is a novel technology for release of endocytosed macromolecules into the cytosol. The… 
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