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Telomere Shortening
Known as:
Shortening, Telomere
, Telomere Shortenings
, Shortenings, Telomere
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The loss of some TELOMERE sequence during DNA REPLICATION of the first several base pairs of a linear DNA molecule; or from DNA DAMAGE. Cells have…
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National Institutes of Health
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Related topics
Related topics
6 relations
CEREBRORETINAL MICROANGIOPATHY WITH CALCIFICATIONS AND CYSTS (disorder)
DYSKERATOSIS CONGENITA, AUTOSOMAL DOMINANT
REVESZ SYNDROME (disorder)
Telomere Homeostasis
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2010
Review
2010
Telomeres and telomerase in cancer.
S. Artandi
,
R. DePinho
Carcinogenesis
2010
Corpus ID: 43322727
Myriad genetic and epigenetic alterations are required to drive normal cells toward malignant transformation. These somatic…
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Highly Cited
2004
Highly Cited
2004
Mechanism of Telomere Shortening by Oxidative Stress
S. Kawanishi
,
S. Oikawa
Annals of the New York Academy of Sciences
2004
Corpus ID: 25933117
Abstract: We investigated whether oxidative stress, which contributes to aging, accelerates the telomere shortening in human…
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Highly Cited
2002
Highly Cited
2002
Senescence Induced by Altered Telomere State, Not Telomere Loss
J. Karlseder
,
A. Smogorzewska
,
T. de Lange
Science
2002
Corpus ID: 21567827
Primary human cells in culture invariably stop dividing and enter a state of growth arrest called replicative senescence. This…
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Highly Cited
2002
Highly Cited
2002
Endothelial Cell Senescence in Human Atherosclerosis: Role of Telomere in Endothelial Dysfunction
T. Minamino
,
H. Miyauchi
,
Toshihiko Yoshida
,
Y. Ishida
,
H. Yoshida
,
I. Komuro
Circulation
2002
Corpus ID: 16954970
Background—The functional changes associated with cellular senescence may be involved in human aging and age-related vascular…
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Highly Cited
1999
Highly Cited
1999
Telomere shortening and apoptosis in telomerase-inhibited human tumor cells.
Xiaoling Zhang
,
V. Mar
,
Wen Zhou
,
L. Harrington
,
M. Robinson
Genes & Development
1999
Corpus ID: 33765714
Despite a strong correlation between telomerase activity and malignancy, the outcome of telomerase inhibition in human tumor…
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Highly Cited
1999
Highly Cited
1999
p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2.
P H Stern
,
D. Feldman
,
+5 authors
Titia De Lange
Science
1999
Corpus ID: 17650387
Although broken chromosomes can induce apoptosis, natural chromosome ends (telomeres) do not trigger this response. It is shown…
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Highly Cited
1998
Highly Cited
1998
Extension of life-span by introduction of telomerase into normal human cells.
A. Bodnar
,
M. Ouellette
,
+7 authors
W. Wright
Science
1998
Corpus ID: 35667874
Normal human cells undergo a finite number of cell divisions and ultimately enter a nondividing state called replicative…
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Highly Cited
1997
Highly Cited
1997
Control of telomere length by the human telomeric protein TRF1
B. Steensel
,
T. Lange
Nature
1997
Corpus ID: 4340857
Human telomeres, the nucleoprotein complexes at chromosome ends, consist of tandem arrays of TTAGGG repeats bound to specific…
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Highly Cited
1995
Highly Cited
1995
Telomere shortening is associated with cell division in vitro and in vivo.
R. Allsopp
,
E. Chang
,
+4 authors
C. Harley
Experimental Cell Research
1995
Corpus ID: 28979712
In humans, the amount of terminal (TTAGGG)n, telomeric DNA decreases during aging of various somatic cell types in vitro and in…
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Highly Cited
1992
Highly Cited
1992
Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.
C. Counter
,
A. Avilion
,
+5 authors
J. Steitz
EMBO Journal
1992
Corpus ID: 14763231
Loss of telomeric DNA during cell proliferation may play a role in ageing and cancer. Since telomeres permit complete replication…
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