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Telomere Shortening

Known as: Shortening, Telomere, Telomere Shortenings, Shortenings, Telomere 
The loss of some TELOMERE sequence during DNA REPLICATION of the first several base pairs of a linear DNA molecule; or from DNA DAMAGE. Cells have… 
National Institutes of Health

Related topics

Related topics

6 relations
CEREBRORETINAL MICROANGIOPATHY WITH CALCIFICATIONS AND CYSTS (disorder)DYSKERATOSIS CONGENITA, AUTOSOMAL DOMINANTREVESZ SYNDROME (disorder)Telomere Homeostasis

Papers overview

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Highly Cited
2005
Highly Cited
2005
An increase in telomere sister chromatid exchange in murine embryonic stem cells possessing critically shortened telomeres.
Telomerase deficiency leads to a progressive loss of telomeric DNA that eventually triggers cell apoptosis in human primary cells… 
Highly Cited
2004
Highly Cited
2004
A G-quadruplex-interactive agent, telomestatin (SOT-095), induces telomere shortening with apoptosis and enhances chemosensitivity in acute myeloid leukemia.
Telomerase, the ribonucleoprotein enzyme maintaining the telomeres of eukaryotic chromosomes, is up-regulated in the vast… 
2004
2004
Telomere shortening in human fibroblasts is not dependent on the size of the telomeric‐3′‐overhang
Telomeres shorten in human somatic cells with each round of DNA replication, and this shortening is thought to ultimately trigger… 
Highly Cited
2003
Highly Cited
2003
Resistance to the Short Term Antiproliferative Activity of the G-quadruplex Ligand 12459 Is Associated with Telomerase Overexpression and Telomere Capping Alteration*
Ligands that stabilize the telomeric G-rich single-stranded DNA overhang into G-quadruplex can be considered as potential… 
Highly Cited
2001
Highly Cited
2001
Ribozyme cleavage of telomerase mRNA sensitizes breast epithelial cells to inhibitors of topoisomerase.
Telomerase activity is necessary and sufficient for immortality in many cells and hence represents a prime target for antitumor… 
Review
2000
Review
2000
Repair of telomeric DNA prior to replicative senescence
1999
1999
Telomere shortening and the clinicopathologic characteristics of human colorectal carcinomas
It has been reported that shortening of telomeres and strong activation of telomerase occur frequently in colorectal carcinomas… 
Highly Cited
1998
Highly Cited
1998
Regulation of telomere length by checkpoint genes in Schizosaccharomyces pombe.
We have studied telomere length in Schizosaccharomyces pombe strains carrying mutations affecting cell cycle checkpoints, DNA… 
Review
1997
Review
1997
Critical telomere shortening regulated by the ataxia-telangiectasia gene acts as a DNA damage signal leading to activation of p53 protein and limited life-span of human diploid fibroblasts. A review.
  • H. Vaziri
  • Biochemistry. Biokhimiia
  • 1997
  • Corpus ID: 2578148
Somatic cells undergo a limited number of doublings in culture and enter an irreversible block in the G1 and G2/M phase of the… 
Highly Cited
1994
Highly Cited
1994
Telomere shortening in renal cell carcinoma.
The ends of human chromosomes consist of a specialized structure, the telomere, composed of repeats of TTAGGG making up a total… 
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