Skip to search formSkip to main contentSkip to account menu

Telomere Shortening

Known as: Shortening, Telomere, Telomere Shortenings, Shortenings, Telomere 
The loss of some TELOMERE sequence during DNA REPLICATION of the first several base pairs of a linear DNA molecule; or from DNA DAMAGE. Cells have… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2010
Review
2010
Myriad genetic and epigenetic alterations are required to drive normal cells toward malignant transformation. These somatic… 
Highly Cited
2004
Highly Cited
2004
Abstract: We investigated whether oxidative stress, which contributes to aging, accelerates the telomere shortening in human… 
Highly Cited
2002
Highly Cited
2002
Primary human cells in culture invariably stop dividing and enter a state of growth arrest called replicative senescence. This… 
Highly Cited
2002
Highly Cited
2002
Background—The functional changes associated with cellular senescence may be involved in human aging and age-related vascular… 
Highly Cited
1999
Highly Cited
1999
Despite a strong correlation between telomerase activity and malignancy, the outcome of telomerase inhibition in human tumor… 
Highly Cited
1999
Highly Cited
1999
Although broken chromosomes can induce apoptosis, natural chromosome ends (telomeres) do not trigger this response. It is shown… 
Highly Cited
1998
Highly Cited
1998
Normal human cells undergo a finite number of cell divisions and ultimately enter a nondividing state called replicative… 
Highly Cited
1997
Highly Cited
1997
Human telomeres, the nucleoprotein complexes at chromosome ends, consist of tandem arrays of TTAGGG repeats bound to specific… 
Highly Cited
1995
Highly Cited
1995
In humans, the amount of terminal (TTAGGG)n, telomeric DNA decreases during aging of various somatic cell types in vitro and in… 
Highly Cited
1992
Highly Cited
1992
Loss of telomeric DNA during cell proliferation may play a role in ageing and cancer. Since telomeres permit complete replication…