Telomere Shortening

Known as: Shortening, Telomere, Telomere Shortenings, Shortenings, Telomere 
The loss of some TELOMERE sequence during DNA REPLICATION of the first several base pairs of a linear DNA molecule; or from DNA DAMAGE. Cells have… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
The shortening of human telomeres has two opposing effects during cancer development. On the one hand, telomere shortening can… (More)
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Highly Cited
2004
Highly Cited
2004
Cellular senescence can be triggered by telomere shortening as well as a variety of stresses and signaling imbalances. We used… (More)
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Highly Cited
2004
Highly Cited
2004
We investigated whether oxidative stress, which contributes to aging, accelerates the telomere shortening in human cultured cells… (More)
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Highly Cited
2002
Highly Cited
2002
Primary human cells in culture invariably stop dividing and enter a state of growth arrest called replicative senescence. This… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND The functional changes associated with cellular senescence may be involved in human aging and age-related vascular… (More)
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Highly Cited
1999
Highly Cited
1999
Maintenance of telomere length and function is critical for the efficient proliferation of eukaryotic cells. Here, we examine the… (More)
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Highly Cited
1999
Highly Cited
1999
Despite a strong correlation between telomerase activity and malignancy, the outcome of telomerase inhibition in human tumor… (More)
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Highly Cited
1998
Highly Cited
1998
Normal human cells undergo a finite number of cell divisions and ultimately enter a nondividing state called replicative… (More)
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Highly Cited
1997
Highly Cited
1997
Human telomeres, the nucleoprotein complexes at chromosome ends, consist of tandem arrays of TTAGGG repeats bound to specific… (More)
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Highly Cited
1992
Highly Cited
1992
Loss of telomeric DNA during cell proliferation may play a role in ageing and cancer. Since telomeres permit complete replication… (More)
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