Role of frizzled 7 in the regulation of convergent extension movements during gastrulation in Xenopus laevis.
- A. Djiane, J. Riou, M. Umbhauer, J. Boucaut, D. Shi
- BiologyDevelopment
- 15 July 2000
The results suggest an endogenous role of Xfz7 in the regulation of convergent extension during gastrulation, and suggest that the wild-type and truncated receptors have opposing effects when coexpressed and that overexpression of X fz7 causes an increased signalling activity.
The Bloom's Syndrome Gene Product Interacts with Topoisomerase III*
- Leonard Wu, S. Davies, I. Hickson
- BiologyJournal of Biological Chemistry
- 31 March 2000
It is shown that Bloom's syndrome gene product BLM and hTOPO IIIα, one of two human topoisomerase III homologues, co-localize in the nucleus of human cells and can be co-immunoprecipitated from human cell extracts.
The C‐terminal cytoplasmic Lys‐Thr‐X‐X‐X‐Trp motif in frizzled receptors mediates Wnt/β‐catenin signalling
- M. Umbhauer, A. Djiane, D. Shi
- BiologyEMBO Journal
- 15 September 2000
Functional evidence supporting a role of this conserved motif in the modulation of Wnt signalling is provided, consistent with the genetic features exhibited by Drosophila Dfz3 and Caenorhabditis elegans mom‐5 in which the tryptophan is substituted by a tyrosine.
Targeting telomeres and telomerase.
- A. De Cian, L. Lacroix, J. Mergny
- BiologyBiochimie
- 2008
Specific phosphorylation of SR proteins by mammalian DNA topoisomerase I
- F. Rossi, E. Labourier, J. Tazi
- Biology, ChemistryNature
- 2 May 1996
The purification of a protein kinase that is specific for SR proteins is reported and it is shown that it is DNA topoisomerase I, which lacks a canonical ATP-binding motif but binds ATP with a dissociation constant of 50 nM.
A novel small molecule that alters shelterin integrity and triggers a DNA-damage response at telomeres.
- R. Rodriguez, S. Müller, J. A. Yeoman, C. Trentesaux, J. Riou, S. Balasubramanian
- Biology, ChemistryJournal of the American Chemical Society
- 1 November 2008
A novel synthetic small molecule is described which shows an unprecedented stabilization of the human telomeric G-quadruplex with high selectivity relative to double-stranded DNA and can be used in vitro to inhibit telomerase activity and to uncap human POT1 from the telomerics G-overhang.
A G-quadruplex structure within the 5′-UTR of TRF2 mRNA represses translation in human cells
The present data substantiate a potential translational mechanism mediated by a G4 RNA motif for the downregulation of TRF2 expression and demonstrate that several highly selective G4 ligands, the pyridine dicarboxamide derivative 360A and bisquinolinium compounds Phen-DC(3) and Phen- DC(6), are able to bind the 91TRF2G:RNA sequence and to modulate TRF 2 protein translation in vitro.
Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways
- J. Gavard, M. Lambert, R. Mège
- BiologyJournal of Cell Science
- 15 January 2004
The formation of de novo contacts was dissected by spreading cells on a highly active N-cadherin homophilic ligand to provide additional information on the mechanisms by which cadherin coordinates adhesion with dynamic changes in the cytoskeleton to control cell shape and intercellular junction organization.
Alternative splicing directs the expression of two D2 dopamine receptor isoforms
- B. Giros, P. Sokoloff, M. Martres, J. Riou, L. Emorine, J. Schwartz
- BiologyNature
- 21 December 1989
It is shown that the gene for the D2 receptor produces two receptor isoforms by alternative messenger RNA splicing, providing a route to receptor diversity in this family of receptors.
Identification of a new metabolite of CPT-11 (irinotecan): pharmacological properties and activation to SN-38.
- H. Dodds, M. Haaz, J. Riou, J. Robert, L. Rivory
- Chemistry, BiologyJournal of Pharmacology and Experimental…
- 1 July 1998
The structure of CPT-11, a water-soluble derivative of camptothecine with promising activity against several types of malignancies, is postulated to be 7-ethyl-10-(4-amino-1-piperidino)carbonyloxycamptotheCine, and this structure was synthesized by Rhône-Poulenc Rorer.
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