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Importance The accumulation of aggregated &bgr;-amyloid and tau proteins into plaques and tangles is a central feature of… Expand Background Amyloid protein precursor (APP), presenilin-1 (PSEN1), and presenilin-2 (PSEN2) mutations cause autosomal dominant… Expand IMPORTANCE
Nocturnal sleep disruption develops in Alzheimer disease (AD) owing to the derangement of the sleep-wake cycle… Expand In comparison to the levels in age and gender-matched controls, reduced levels of pathological amyloid-β protein in cerebrospinal… Expand Intracytoplasmic proteinaceous inclusions, primarily composed of tau or α-synuclein (α-syn), are predominant pathological… Expand OBJECTIVE
To identify biomarker patterns typical for Alzheimer disease (AD) in an independent, unsupervised way, without using… Expand CONTEXT
Small single-center studies have shown that cerebrospinal fluid (CSF) biomarkers may be useful to identify incipient… Expand BACKGROUND
Phosphorylation of tau protein at threonine 231 (using full-length tau, 441 amino acids, for the numbering scheme) (p… Expand Abstract—In this longitudinal study of 77 patients with mild cognitive impairment (MCI), the authors analyzed whether levels of… Expand Calcium/calmodulin (CaM)-dependent protein kinases isolated from bovine and rat brains phosphorylate the microtubule-associated… Expand