Targeted Therapy

A type of treatment that uses drugs or other substances, such as monoclonal antibodies, to identify and attack specific cancer cells. Targeted… (More)
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
BACKGROUND Previous prognostic models for second-line systemic therapy in patients with metastatic renal cell carcinoma have not… (More)
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Review
2014
Review
2014
Interleukin-6 (IL-6) is a pleiotropic cytokine with significant functions in the regulation of the immune system. As a potent pro… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND The anti-HER2 monoclonal antibody trastuzumab and the tyrosine kinase inhibitor lapatinib have complementary… (More)
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Highly Cited
2011
Highly Cited
2011
BACKGROUND Analysis of prognostic factors for progression-free survival (PFS) and overall survival (OS) was performed using final… (More)
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Review
2009
Review
2009
The epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs), gefitinib and erlotinib, are reversible competitive… (More)
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Review
2008
Review
2008
Vascular endothelial growth factor (VEGF)-targeted therapy has become an important treatment option for the management of a… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Therapy targeted against the vascular endothelial growth factor (VEGF) pathway is a standard of care for patients with… (More)
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Highly Cited
2007
Highly Cited
2007
OBJECTIVE To explore the role of surgery of residual disease following a period of therapy with imatinib mesylate in advanced… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Traditional cytotoxic approaches to tumor management are associated with efficacy and toxicity limitations. Blockade… (More)
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Review
2001
Review
2001
In the year 2000, an estimated 1220 100 new cases of invasive cancer will be diagnosed in the United States, and about 552 200… (More)
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