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Abstract The aim of the present investigation was to formulate tapentadol hydrochloride–loaded chitosan nanoparticles (CS-NPs… Expand Tapentadol is a novel, centrally acting analgesic with dual mechanism of action, combining mu-opioid receptor agonism with… Expand Two simple, fast, environmental friendly and reliable spectrophotometric methods were developed for determination of tapentadol… Expand AIMS
To examine whether tamper-resistant formulations (TRFs) of tapentadol hydrochloride extended-release (ER) 50 mg (TAP50) and… Expand The crystal and molecular structures of four stereoisomers of tapentadol hydrochloride [systematic name: 3-(3-hydroxyphenyl)-N,N… Expand Recovery from ambulatory surgical procedures can be limited by postoperative pain. Inadequate analgesia may delay or prevent… Expand Tapentadol exerts its analgesic effects through micro opioid receptor agonism and noradrenaline reuptake inhibition in the… Expand BACKGROUND
Tapentadol hydrochloride is a centrally acting oral analgesic approved by the US Food and Drug Administration in… Expand OBJECTIVE
To review the pharmacodynamics, pharmacokinetics, clinical efficacy, tolerability, dosing, and administration of… Expand