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Tankyrases

Known as: TRF-1 Interacting, Ankyrin-Related, ADP-Ribose Polymerases, Tankyrases [Chemical/Ingredient] 
A group of telomere associated proteins that interact with TRF1 PROTEIN, contain ANKYRIN REPEATS and have poly(ADP-ribose) polymerase activity.
National Institutes of Health

Related topics

Related topics

14 relations
In BloodProcess of secretionTNKS geneantagonists & inhibitors

Narrower (6)

PME-1 protein, C elegansPME-2 protein, C elegansPme-5 protein, C elegansTNKS protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
In silico studies on potential TNKS inhibitors: a combination of pharmacophore and 3D-QSAR modelling, virtual screening, molecular docking and molecular dynamics
Abstract Maladjustment of the Wnt-signalling pathway can lead to a variety of cancers. Axin can be expressed stably through the… 
2018
2018
Tankyrase regulates apoptosis by activating JNK signaling in Drosophila.
2018
2018
Régulation du suppresseur d'invasion Arpin par les Tankyrases
Le complexe Arp2/3, conserve sur le plan evolutif, joue un role central dans la nucleation d’actine branchee, qui entraine la… 
2017
2017
Discovery of new dual binding TNKS inhibitors of Wnt signaling inhibition by pharmacophore modeling, molecular docking and bioassay.
Tankyrases (TNKS), key transmitters in the Wnt signaling pathway which is very conservative in evolution, are vital targets as… 
2017
2017
Running title : Wnt / β-catenin in corpus luteum development and function
Running title: Wnt/β-catenin in corpus luteum development and function. Accialini Paula, Irusta Griselda, Bechis Andres, Bas… 
2016
2016
The binding mechanism of a novel nicotinamide isostere inhibiting with TNKSs: a molecular dynamic simulation and binding free energy calculation
Tankyrases (TNKSs), a member of human poly (ADP-ribose) polymerase (PARP) protein superfamily, plays a key role in regulation of… 
Highly Cited
2013
Highly Cited
2013
Fragment-based ligand design of novel potent inhibitors of tankyrases.
Tankyrases constitute potential drug targets for cancer and myelin-degrading diseases. We have applied a structure- and… 
2013
2013
Structure-efficiency relationship of [1,2,4]triazol-3-ylamines as novel nicotinamide isosteres that inhibit tankyrases.
Tankyrases 1 and 2 are members of the poly(ADP-ribose) polymerase (PARP) family of enzymes that modulate Wnt pathway signaling… 
2009
2009
The DNA damage-inducible C. elegans tankyrase is a nuclear protein closely linked to chromosomes
Tankyrases are protein members of the poly(ADP-ribose) polymerase family bearing several ankyrin domain and a WGR domain. They… 
1999
1999
Tankyrases, trfi binding protein
(57) Abstract: The present invention is unique proteins vertebrate, discloses tankyrase. Tankyrase binds to telomeric repeat… 
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