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Taladegib

Known as: 4-Fluoro-N-methyl-N-(1-(4-(1-methyl-1H-pyrazol-5-yl)phthalazin-1-yl)piperidin-4-yl)-2-(trifluoromethyl)benzamide, Benzamide, 4-Fluoro-N-methyl-N-(1-(4-(1-methyl-1H-pyrazol-5-yl)-1-phthalazinyl)-4-piperidinyl)-2-(trifluoromethyl)- 
An orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic… 
National Institutes of Health

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LY2940680
NCIt Antineoplastic Agent Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Design, synthesis and biological evaluation of anthranilamide derivatives as potent SMO inhibitors.
2020
2020
Taladegib controls early chondrocyte hypertrophy via inhibiting smoothened/Gli1 pathway.
Chondrocyte hypertrophy is a common phenomenon in osteoarthritis (OA). Indian hedgehog (Ihh) is secreted by pre-hypertrophic… 
Review
2019
Review
2019
Hedgehog Pathway Inhibition for the Treatment of Basal Cell Carcinoma
Globally, basal cell carcinoma is the most commonly diagnosed cancer. While most cases are amenable to surgery, treatment options… 
2018
2018
Synthesis and evaluation of novel dimethylpyridazine derivatives as hedgehog signaling pathway inhibitors.
Highly Cited
2018
Highly Cited
2018
Phase I Study of LY2940680, a Smo Antagonist, in Patients with Advanced Cancer Including Treatment-Naïve and Previously Treated Basal Cell Carcinoma
Purpose: The purpose of this study was to determine a recommended phase II dose and schedule of LY2940680 (taladegib) for safe… 
2018
2018
Deciphering structural stability and binding mechanisms of potential antagonists with smoothened protein
Identification of new potential inhibitors against Hedgehog pathway activator protein Smoothened (SMO) is considered to be of… 
2017
2017
Design, synthesis, and biological evaluation of optimized phthalazine derivatives as hedgehog signaling pathway inhibitors.
Review
2017
Review
2017
Development of taladegib as a sonic hedgehog signaling pathway inhibitor
2016
2016
Pharmacological evaluation of a series of smoothened antagonists in signaling pathways and after topical application in a depilated mouse model
The Hedgehog (HH) pathway has been linked to the formation of basal cell carcinoma (BCC), medulloblastoma, and other cancers. The… 
Review
2016
Review
2016
Oral therapy for nonmelanoma skin cancer in patients with advanced disease and large tumor burden: a review of the literature with focus on a new generation of targeted therapies
Nonmelanoma skin cancer (NMSC) is the most common cancer in patients and includes basal cell carcinoma (BCC) and squamous cell… 
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