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LY2940680

Known as: LY-2940680 
 
National Institutes of Health

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2 relations

Broader (2)

PhthalazinesTaladegib

Papers overview

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2018
2018
Phase I Study of LY2940680, a Smo Antagonist, in Patients with Advanced Cancer Including Treatment-Naïve and Previously Treated Basal Cell Carcinoma.
Purpose: The purpose of this study was to determine a recommended phase II dose and schedule of LY2940680 (taladegib) for safe… Expand
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2016
2016
Pharmacological evaluation of a series of smoothened antagonists in signaling pathways and after topical application in a depilated mouse model
The Hedgehog (HH) pathway has been linked to the formation of basal cell carcinoma (BCC), medulloblastoma, and other cancers. The… Expand
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Review
2015
Review
2015
Molecular pathways: novel approaches for improved therapeutic targeting of Hedgehog signaling in cancer stem cells.
The Hedgehog (Hh) signaling pathway is critical for embryonic development. In adult tissues, Hh signaling is relatively quiescent… Expand
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2015
2015
Sensitivity of Human Intrahepatic Cholangiocarcinoma Subtypes to Chemotherapeutics and Molecular Targeted Agents: A Study on Primary Cell Cultures
We investigated the sensitivity of intrahepatic cholangiocarcinoma (IHCCA) subtypes to chemotherapeutics and molecular targeted… Expand
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2015
2015
MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor.
The Smoothened (Smo) receptor, a member of class F G protein-coupled receptors, is the main transducer of the Hedgehog (Hh… Expand
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2014
2014
Molecular modeling study on the dynamical structural features of human smoothened receptor and binding mechanism of antagonist LY2940680 by metadynamics simulation and free energy calculation.
BACKGROUND The smoothened (SMO) receptor, one of the Class F G protein coupled receptors (GPCRs), is an essential component of… Expand
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Review
2014
Review
2014
Emerging drugs and combination strategies for basal cell carcinoma.
INTRODUCTION Basal cell carcinoma (BCC) is a malignancy that is driven by an activated Hedgehog (Hh) pathway. Smoothened… Expand
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2014
2014
Potential Smoothened Inhibitor from Traditional Chinese Medicine against the Disease of Diabetes, Obesity, and Cancer
Nowadays, obesity becomes a serious global problem, which can induce a series of diseases such as type 2 diabetes mellitus… Expand
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Highly Cited
2013
Highly Cited
2013
Structure of the human smoothened receptor bound to an antitumour agent
The smoothened (SMO) receptor, a key signal transducer in the hedgehog signalling pathway, is responsible for the maintenance of… Expand
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2012
2012
594 A Phase I Dose-escalation, Pharmacokinetic (PK) and Pharmacodynamic (PD) Evaluation of LY2940680, an Oral Smo Inhibitor
 
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