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LY2940680
Known as:
LY-2940680
National Institutes of Health
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Related topics
Related topics
2 relations
Broader (2)
Phthalazines
Taladegib
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Design, synthesis and biological evaluation of anthranilamide derivatives as potent SMO inhibitors.
Dezhong Ji
,
Wanwan Zhang
,
Yungen Xu
,
Jing-jing Zhang
Bioorganic & medicinal chemistry
2020
Corpus ID: 211135303
2018
2018
Phase I Study of LY2940680, a Smo Antagonist, in Patients with Advanced Cancer Including Treatment-Naïve and Previously Treated Basal Cell Carcinoma
J. Bendell
,
V. André
,
+8 authors
D. V. Von Hoff
Clinical Cancer Research
2018
Corpus ID: 3564587
Purpose: The purpose of this study was to determine a recommended phase II dose and schedule of LY2940680 (taladegib) for safe…
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2017
2017
A structurally guided dissection-then-evolution strategy for ligand optimization of smoothened receptor† †The authors declare no competing interests. ‡ ‡Electronic supplementary information (ESI…
Lintao Ye
,
K. Ding
,
+10 authors
H. Tao
MedChemComm
2017
Corpus ID: 29460826
We present herein a novel dissection-then-evolution strategy for ligand optimization.
2016
2016
Pharmacological evaluation of a series of smoothened antagonists in signaling pathways and after topical application in a depilated mouse model
E. Lauressergues
,
P. Heusler
,
+12 authors
D. Cussac
Pharmacology research & perspectives
2016
Corpus ID: 18011214
The Hedgehog (HH) pathway has been linked to the formation of basal cell carcinoma (BCC), medulloblastoma, and other cancers. The…
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Review
2015
Review
2015
Molecular Pathways: Novel Approaches for Improved Therapeutic Targeting of Hedgehog Signaling in Cancer Stem Cells
V. Justilien
,
A. Fields
Clinical Cancer Research
2015
Corpus ID: 11516263
The Hedgehog (Hh) signaling pathway is critical for embryonic development. In adult tissues, Hh signaling is relatively quiescent…
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2015
2015
Sensitivity of Human Intrahepatic Cholangiocarcinoma Subtypes to Chemotherapeutics and Molecular Targeted Agents: A Study on Primary Cell Cultures
A. Fraveto
,
V. Cardinale
,
+13 authors
D. Alvaro
PloS one
2015
Corpus ID: 15368500
We investigated the sensitivity of intrahepatic cholangiocarcinoma (IHCCA) subtypes to chemotherapeutics and molecular targeted…
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2015
2015
MRT‐92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor
L. Hoch
,
H. Faure
,
+9 authors
M. Ruat
FASEB journal : official publication of the…
2015
Corpus ID: 6383078
The Smoothened (Smo) receptor, a member of class F G protein‐coupled receptors, is the main transducer of the Hedgehog (Hh…
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Review
2014
Review
2014
Emerging drugs and combination strategies for basal cell carcinoma
J. Dreier
,
R. Dummer
,
L. Felderer
,
M. Nägeli
,
S. Gobbi
,
R. Kunstfeld
Expert opinion on emerging drugs
2014
Corpus ID: 22605845
Introduction: Basal cell carcinoma (BCC) is a malignancy that is driven by an activated Hedgehog (Hh) pathway. Smoothened…
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2014
2014
Molecular modeling study on the dynamical structural features of human smoothened receptor and binding mechanism of antagonist LY2940680 by metadynamics simulation and free energy calculation.
Qifeng Bai
,
Yulin Shen
,
N. Jin
,
Huanxiang Liu
,
X. Yao
Biochimica et biophysica acta
2014
Corpus ID: 38962484
Highly Cited
2013
Highly Cited
2013
Structure of the human smoothened receptor bound to an antitumour agent
Chong Wang
,
Huixian Wu
,
+7 authors
R. Stevens
Nature
2013
Corpus ID: 4427989
The smoothened (SMO) receptor, a key signal transducer in the hedgehog signalling pathway, is responsible for the maintenance of…
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