TXNIP gene

Known as: Thioredoxin Interacting Protein Gene, VITAMIN D3-UPREGULATED PROTEIN 1, THIOREDOXIN-INTERACTING PROTEIN 
This gene plays a role in the regulation of stress response signaling.
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Thioredoxin-interacting protein (TXNIP) is an α-arrestin family protein that is induced in response to glucose elevation. It has… (More)
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Highly Cited
2012
Highly Cited
2012
When unfolded proteins accumulate to irremediably high levels within the endoplasmic reticulum (ER), intracellular signaling… (More)
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Highly Cited
2011
Highly Cited
2011
Recent studies have shown that 3-Deazaneplanocin A (DZNep), a histone methyltransferase inhibitor, disrupts polycomb-repressive… (More)
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Highly Cited
2011
Highly Cited
2011
OBJECTIVE Obesity is characterized by elevated levels of proinflammatory cytokines, including interleukin (IL)-1β, that… (More)
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Highly Cited
2010
Highly Cited
2010
The NLRP3 inflammasome has a major role in regulating innate immunity. Deregulated inflammasome activity is associated with… (More)
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Highly Cited
2009
Highly Cited
2009
Chronic hyperglycemia and activation of receptor for advanced glycation end products (RAGE) are known risk factors for… (More)
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Highly Cited
2009
Highly Cited
2009
Recently, we identified Txnip (thioredoxin-interacting protein) as a mediator of glucotoxic beta cell death and discovered that… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Type 2 diabetes mellitus (T2DM) is characterized by defects in insulin secretion and action. Impaired glucose uptake… (More)
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Highly Cited
2003
Highly Cited
2003
Loss of genetic material on chromosome 6 has been associated with progression of human melanomas. We showed previously that… (More)
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Highly Cited
2002
Highly Cited
2002
Familial combined hyperlipidemia (FCHL, MIM-144250) is a common, multifactorial and heterogeneous dyslipidemia predisposing to… (More)
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