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TWIST2 gene

Known as: TWIST, DROSOPHILA, HOMOLOG OF, 2, bHLHa39, Dermo-1 
This gene plays a role in the negative regulation of both gene transcription and osteoblast differentiation.
National Institutes of Health

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Homo sapiensNegative Regulation of Cell DifferentiationTWIST2 protein, humanTranscriptional Regulation
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TWIST2 wt Allele

Papers overview

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Highly Cited
2017
Highly Cited
2017
MicroRNA-221-3p, a TWIST2 target, promotes cervical cancer metastasis by directly targeting THBS2
MicroRNAs have implicated in the relapse and metastasis of cervical cancer, which is the leading cause of cervical cancer-related… 
Highly Cited
2015
Highly Cited
2015
Establishing Criteria for Human Mesenchymal Stem Cell Potency
This study sought to identify critical determinants of mesenchymal stem cell (MSC) potency using in vitro and in vivo attributes… 
Highly Cited
2013
Highly Cited
2013
Down-regulation of miR-138 promotes colorectal cancer metastasis via directly targeting TWIST2
BackgroundColorectal cancer (CRC) is the most common digestive system malignancy. The molecular events involved in the… 
Highly Cited
2011
Highly Cited
2011
Osteoblast connexin43 modulates skeletal architecture by regulating both arms of bone remodeling
Cx43 in osteogenic cells controls both arms of the bone-remodeling cycle via direct actions on osteoblast differentiation and… 
Highly Cited
2011
Highly Cited
2011
Overexpression of TWIST2 correlates with poor prognosis in Head and Neck Squamous Cell Carcinomas
Head and neck squamous cell carcinomas (HNSCC) are a heterogeneous group of tumors with variable presentation and clinical… 
Highly Cited
2009
Highly Cited
2009
TWIST Family of Basic Helix‐Loop‐Helix Transcription Factors Mediate Human Mesenchymal Stem Cell Growth and Commitment
The TWIST family of basic helix‐loop‐helix transcription factors, Twist‐1 and Dermo‐1 are known mediators of mesodermal tissue… 
Highly Cited
2005
Highly Cited
2005
TWIST2 demonstrates differential methylation in immunoglobulin variable heavy chain mutated and unmutated chronic lymphocytic leukemia.
PURPOSE Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease for which natural history can be predicted based… 
Highly Cited
2000
Highly Cited
2000
Human Dermo-1 has attributes similar to twist in early bone development.
Highly Cited
1999
Highly Cited
1999
Twist is a potential oncogene that inhibits apoptosis.
Oncogene activation increases susceptibility to apoptosis. Thus, tumorigenesis must depend, in part, on compensating mutations… 
Highly Cited
1995
Highly Cited
1995
Dermo-1: a novel twist-related bHLH protein expressed in the developing dermis.
Transcription factors belonging to the basic helix-loop-helix (bHLH) family have been shown to control differentiation of a… 
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