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TWIST2 gene

Known as: TWIST, DROSOPHILA, HOMOLOG OF, 2, bHLHa39, Dermo-1 
This gene plays a role in the negative regulation of both gene transcription and osteoblast differentiation.
National Institutes of Health

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Related topics

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Homo sapiensNegative Regulation of Cell DifferentiationTWIST2 protein, humanTranscriptional Regulation

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TWIST2 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Regulation of p21 by TWIST2 contributes to its tumor-suppressor function in human acute myeloid leukemia
TWIST2 has a dual function in tumors. Its implication in the initiation and metastasis of various solid tumors is well… 
Highly Cited
2013
Highly Cited
2013
Down-regulation of miR-138 promotes colorectal cancer metastasis via directly targeting TWIST2
BackgroundColorectal cancer (CRC) is the most common digestive system malignancy. The molecular events involved in the… 
2013
2013
Conditional Deletion of Cytochrome P450 Reductase in Osteoprogenitor Cells Affects Long Bone and Skull Development in Mice Recapitulating Antley-Bixler Syndrome: Role of a Redox Enzyme in Development
NADPH-cytochrome P450 oxidoreductase (POR) is the primary electron donor for cytochromes P450, dehydrocholesterol reductase, heme… 
Highly Cited
2012
Highly Cited
2012
Correlation of TWIST2 up-regulation and epithelial-mesenchymal transition during tumorigenesis and progression of cervical carcinoma.
2012
2012
Epigenetic inactivation of TWIST2 in acute lymphoblastic leukemia modulates proliferation, cell survival and chemosensitivity
Background Altered regulation of many transcription factors has been shown to be important in the development of leukemia. TWIST2… 
2012
2012
Significance of Heterogeneous Twist2 Expression in Human Breast Cancers
Background Twist2 (Dermo1) has been shown to mediate the epithelial-mesenchymal transition (EMT) to promote tumor invasion and… 
Review
2011
Review
2011
Setleis syndrome in Mexican-Nahua sibs due to a homozygous TWIST2 frameshift mutation and partial expression in heterozygotes: review of the focal facial dermal dysplasias and subtype…
Background The focal facial dermal dysplasias (FFDDs) are a group of inherited disorders of facial development, characterised by… 
2011
2011
Nonsense mutations of the bHLH transcription factor TWIST2 found in Setleis Syndrome patients cause dysregulation of periostin.
2008
2008
Development of the carapacial ridge: implications for the evolution of genetic networks in turtle shell development
SUMMARY Paleontologists and neontologists have long looked to development to understand the homologies of the dermal bones that… 
1999
1999
Identification of DERMO‐1 as a member of helix‐loop‐helix type transcription factors expressed in osteoblastic cells
Several members of the basic helix‐loop‐helix (bHLH) type of transcription factors have now been reported, and almost every… 
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