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TUG-891

National Institutes of Health

Papers overview

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Review
2020
Review
2020
Characterization of the metabolites of TUG-891 in rat, dog and human hepatocytes by ultra-high performance liquid chromatography tandem mass spectrometry and nuclear magnetic resonance spectroscopy.
RATIONALE TUG-891 is a potent and selective agonist of the long chain free fatty acid receptor 4. However, its metabolic profiles… 
2020
2020
Regulation of cell survival through free fatty acid receptor 1 (FFA1) and FFA4 induced by endothelial cells in osteosarcoma cells
Abstract Free fatty acid receptor 1 (FFA1) and FFA4 belong to a family of free fatty acid (FFA) receptors. FFA1- and FFA4… 
2020
2020
Simultaneous determination of TUG-891 and its metabolites in rat plasma by liquid chromatography high resolution mass spectrometry with application to preclinical pharmacokinetic study.
In this study, a simple and reliable liquid chromatography tandem mass spectrometry method was first proposed for simultaneous… 
2019
2019
Docosahexaenoic acid and TUG-891 activate free fatty acid-4 receptor in bovine neutrophils.
2017
2017
Improving metabolic stability with deuterium: The discovery of GPU-028, a potent free fatty acid receptor 4 agonists.
2017
2017
Desensitisation of the human long chain fatty acid receptors FFA1 and FFA4
G protein-coupled receptors (GPCRs) constitute the largest, most ubiquitous and most versatile family of membrane proteins… 
2015
2015
Cloning and Characterization of Spliced Variants of the Porcine G Protein Coupled Receptor 120
The polyunsaturated fatty acids (PUFAs) receptor GPR120 exerts a significant impact on systemic nutrient homeostasis in human and… 
2015
2015
Biomarkers in Lung Diseases : from Pathogenesis to Prediction to New Therapies Novel identification of the free fatty acid receptor FFAR 1 that promotes contraction in airway smooth muscle
Kentaro Mizuta, Yi Zhang, Fumiko Mizuta, Hiroshi Hoshijima, Toshiya Shiga, Eiji Masaki, and Charles W. Emala Sr. Department of… 
2014
2014
Effects of eicosapentaenoic acid and the GPR120 agonist TUG‐891 on lysophosphatidic acid signaling in human prostate cancer cells (1066.10)
There is a high incidence of prostate cancer in the Western world, which may be partially attributed to Western diets that are… 
2013
2013
The pharmacology of a potent and selective agonist, TUG-891, demonstrates both potential opportunity and possible challenges to therapeutic agonism of FFA4 (GPR120)
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