TTK Protein Kinase

Known as: MPS1L1, Phosphotyrosine-Picked Threonine Kinase, TTK 
Dual specificity protein kinase TTK (857 aa, ~97 kDa) is encoded by the human TTK gene. This protein is involved in mitotic checkpoint regulation.
National Institutes of Health

Papers overview

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2014
2014
Background:Pancreatic ductal adenocarcinoma (PDAC) is among the most aggressive human malignancies with an overall 5-year… (More)
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2013
2013
Triple-negative breast cancer (TNBC) represents a subgroup of breast cancers (BC) associated with the most aggressive clinical… (More)
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2013
2013
PURPOSE Frameshift mutations in coding mononucleotide repeats (cMNR) are common in tumors with high microsatellite instability… (More)
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2009
2009
Cell cycle progression is monitored constantly to ensure faithful passage of genetic codes and genome stability. We have… (More)
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2008
2008
Upon exposure to genotoxic stress, the c-Abl tyrosine kinase is released from cytoplasmic 14-3-3 proteins and then is targeted to… (More)
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2005
2005
CHK2/hCds1 plays important roles in the DNA damage-induced cell cycle checkpoint by phosphorylating several important targets… (More)
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2004
2004
Chromosome segregation in mitosis is orchestrated by dynamic interaction between spindle microtubule and the kinetochore. Our… (More)
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1994
1994
TTK is a novel protein kinase detectable in all proliferating human cells and tissues. Expression of the TTK gene is markedly… (More)
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Highly Cited
1992
Highly Cited
1992
We have isolated the full-length sequence for a unique human kinase, designated TTK. TTK was initially identified by screening of… (More)
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1992
1992
A novel protein kinase, the Esk kinase, has been isolated from an embryonal carcinoma (EC) cell line by using an expression… (More)
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