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TRV130

National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Machine Learning Harnesses Molecular Dynamics to Discover New $\mu$ Opioid Chemotypes
Computational chemists typically assay drug candidates by virtually screening compounds against crystal structures of a protein… 
Review
2018
Review
2018
Can oliceridine (TRV130), an ideal novel µ receptor G protein pathway selective (µ-GPS) modulator, provide analgesia without opioid-related adverse reactions?
All drugs have both favorable therapeutic and untoward adverse effects. Conventional opioid analgesics possess both analgesia and… 
Review
2018
Review
2018
Biased mu-opioid receptor agonists confer analgesia with reduced side effects
Opioids are considered mainstay treatments for acute and terminal pain. In recent decades, however, overprescription and the… 
2017
2017
APOLLO-1: a Randomized, Controlled, Phase 3 Study of Oliceridine (TRV130) for the Treatment of Moderate to Severe Pain Following Bunionectomy
2017
2017
Abuse-related effects of the biased mu opioid receptor agonist trv130 on intracranial selfstimulation in rats
2017
2017
I1. A Randomized, Placebo- and Active-Controlled Phase 2b Study Investigating Oliceridine (TRV130)
2016
2016
Dose Interruptions with Morphine vs Oliceridine (TRV130), a Novel μ Receptor G Protein Pathway Selective (μ-GPS) Modulator: Analysis from a Placebo- and Morphine-Controlled Phase 2b Study in Patients…
2014
2014
agonism of the l-opioid receptor by TRV 130 increases analgesia and reduces on-target adverse effects versus morphine : A randomized , double-blind , placebo-controlled , crossover study in healthy
Opioids provide powerful analgesia but also efficacy-limiting adverse effects, including severe nausea, vomiting, and respiratory… 
2013
2013
First Human Dosing Experience with TRV130, a Biased Ligand at the Mu Opioid Receptor (P02.013)
OBJECTIVE: To evaluate the safety, tolerability, PK and PD of TRV130. BACKGROUND: TRV130 is a novel highly selective G-protein… 
2013
2013
. 5 ] decan-9-yl ] ethyl } ) amine ( TRV 130 ) , for the Treatment of Acute Severe Pain
The concept of “ligand bias” at G protein coupled receptors has been introduced to describe ligands which preferentially… 
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