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Brugada syndrome (BrS) is a condition defined by ST-segment alteration in right precordial leads and a risk of sudden death… Expand Very recently, mutations in the TRPM4 gene have been identified in four pedigrees as the cause of an autosomal dominant form of… Expand Background—Isolated cardiac conduction block is a relatively common condition in young and elderly populations. Genetic… Expand Progressive familial heart block type I (PFHBI) is a progressive cardiac bundle branch disease in the His-Purkinje system that… Expand Transient receptor potential (TRP) channel, melastatin subfamily (TRPM)4 is a Ca2+‐activated monovalent cation channel that… Expand Non-selective cation (NSC) channels activated by intracellular Ca2+ ([Ca2+]i) play an important role in Ca2+ signaling and… Expand Local control of cerebral blood flow is regulated in part through myogenic constriction of resistance arteries. Although this… Expand TRPM4 has recently been described as a calcium-activated nonselective (CAN) cation channel that mediates membrane depolarization… Expand TRPM4 is a Ca2+-activated but Ca2+-impermeable cation channel. An increase of [Ca2+]i induces activation and subsequent reduction… Expand Calcium-activated nonselective (CAN) cation channels are expressed in various excitable and nonexcitable cells supporting… Expand