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TRIM5 wt Allele

Known as: RNF88, TRIM5alpha, Tripartite Motif Containing 5 wt Allele 
Human TRIM5 wild-type allele is located in the vicinity of 11p15 and is approximately 275 kb in length. This allele, which encodes tripartite motif… 
National Institutes of Health

Related topics

Related topics

3 relations
11p15Antiviral Response

Broader (1)

TRIM5 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Identification of residues within the L2 region of rhesus TRIM5alpha that are required for retroviral restriction and cytoplasmic body localization.
2010
2010
Species-Specific Inhibition of Foamy Viruses from South American Monkeys by New World Monkey TRIM5α Proteins
ABSTRACT Foamy virus evolution closely parallels that of the host species, indicating virus-host coadaptation. We studied simian… 
Highly Cited
2008
Highly Cited
2008
Efficient transduction of pigtailed macaque hematopoietic repopulating cells with HIV-based lentiviral vectors.
Lentiviral vectors are attractive for hematopoietic stem cell (HSC) gene therapy because they do not require mitosis for nuclear… 
Highly Cited
2008
Highly Cited
2008
A human TRIM5alpha B30.2/SPRY domain mutant gains the ability to restrict and prematurely uncoat B-tropic murine leukemia virus.
Highly Cited
2008
Highly Cited
2008
Human immunodeficiency virus type 1 restriction by human-rhesus chimeric tripartite motif 5alpha (TRIM 5alpha) in CD34(+) cell-derived macrophages in vitro and in T cells in vivo in severe combined…
Species-specific innate resistance against viral infections offers novel avenues for antiviral therapeutics. The retroviral… 
2007
2007
Unique features of TRIM5alpha among closely related human TRIM family members.
The tripartite motif (TRIM) protein, TRIM5alpha, restricts some retroviruses, including human immunodeficiency virus (HIV-1… 
Highly Cited
2007
Highly Cited
2007
The design of artificial retroviral restriction factors.
Highly Cited
2007
Highly Cited
2007
The ability of multimerized cyclophilin A to restrict retrovirus infection.
2007
2007
Fusion of Cyclophilin A to Fv1 Enables Cyclosporine-Sensitive Restriction of Human and Feline Immunodeficiency Viruses
ABSTRACT TRIM5α is a potent intracellular antiviral restriction factor governing species-specific retroviral replication. In the… 
Highly Cited
2005
Highly Cited
2005
TRIM5alpha association with cytoplasmic bodies is not required for antiretroviral activity.
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