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TRIM5 wt Allele
Known as:
RNF88
, TRIM5alpha
, Tripartite Motif Containing 5 wt Allele
Human TRIM5 wild-type allele is located in the vicinity of 11p15 and is approximately 275 kb in length. This allele, which encodes tripartite motif…
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National Institutes of Health
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Related topics
Related topics
3 relations
11p15
Antiviral Response
Broader (1)
TRIM5 gene
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Human TRIM Gene Expression in Response to Interferons
L. Carthagena
,
A. Bergamaschi
,
+8 authors
S. Nisole
PLoS ONE
2009
Corpus ID: 13316669
Background Tripartite motif (TRIM) proteins constitute a family of proteins that share a conserved tripartite architecture. The…
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Highly Cited
2007
Highly Cited
2007
Structural basis for PRYSPRY-mediated tripartite motif (TRIM) protein function
L. James
,
A. H. Keeble
,
Zahra Khan
,
D. Rhodes
,
J. Trowsdale
Proceedings of the National Academy of Sciences…
2007
Corpus ID: 10611564
The human tripartite motif (TRIM) family comprises 70 members, including HIV restriction factor TRIM5α and disease-associated…
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Highly Cited
2006
Highly Cited
2006
Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5alpha restriction factor.
Matthew H. Stremlau
,
M. Perron
,
+7 authors
J. Sodroski
Proceedings of the National Academy of Sciences…
2006
Corpus ID: 13059062
The host restriction factor TRIM5alpha mediates species-specific, early blocks to retrovirus infection; susceptibility to these…
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Highly Cited
2006
Highly Cited
2006
Proteasome inhibitors uncouple rhesus TRIM5alpha restriction of HIV-1 reverse transcription and infection.
Xiaolu Wu
,
Jenny L Anderson
,
E. Campbell
,
A. Joseph
,
T. Hope
Proceedings of the National Academy of Sciences…
2006
Corpus ID: 37539605
The primate TRIM5alpha proteins have recently been defined as cellular restriction factors, preventing primate infection by…
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Highly Cited
2006
Highly Cited
2006
All Three Variable Regions of the TRIM5α B30.2 Domain Can Contribute to the Specificity of Retrovirus Restriction
S. Ohkura
,
M. Yap
,
T. Sheldon
,
J. Stoye
Journal of Virology
2006
Corpus ID: 25659343
ABSTRACT Recent studies have revealed the contribution of TRIM5α to retrovirus restriction in cells from a variety of primate…
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Highly Cited
2005
Highly Cited
2005
Positive selection of primate TRIM5alpha identifies a critical species-specific retroviral restriction domain.
S. Sawyer
,
Lily I. Wu
,
M. Emerman
,
Harmit S. Malik
Proceedings of the National Academy of Sciences…
2005
Corpus ID: 22704742
Primate genomes encode a variety of innate immune strategies to defend themselves against retroviruses. One of these, TRIM5alpha…
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Highly Cited
2005
Highly Cited
2005
A Single Amino Acid Change in the SPRY Domain of Human Trim5α Leads to HIV-1 Restriction
M. Yap
,
S. Nisole
,
J. Stoye
Current Biology
2005
Corpus ID: 1910582
Highly Cited
2005
Highly Cited
2005
Species-Specific Variation in the B30.2(SPRY) Domain of TRIM5α Determines the Potency of Human Immunodeficiency Virus Restriction
Matthew H. Stremlau
,
M. Perron
,
Sohanya Welikala
,
J. Sodroski
Journal of Virology
2005
Corpus ID: 45279067
ABSTRACT Retroviruses encounter dominant postentry restrictions in cells of particular species. Human immunodeficiency virus type…
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Highly Cited
2005
Highly Cited
2005
Human Tripartite Motif 5α Domains Responsible for Retrovirus Restriction Activity and Specificity
D. Pérez-Caballero
,
T. Hatziioannou
,
A. Yang
,
S. Cowan
,
P. Bieniasz
Journal of Virology
2005
Corpus ID: 929839
ABSTRACT The tripartite motif 5α protein (TRIM5α) is one of several factors expressed by mammalian cells that inhibit retrovirus…
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Highly Cited
2004
Highly Cited
2004
The human and African green monkey TRIM5alpha genes encode Ref1 and Lv1 retroviral restriction factor activities.
Z. Keckesova
,
L. Ylinen
,
G. Towers
Proceedings of the National Academy of Sciences…
2004
Corpus ID: 40037446
The rhesus macaque tripartite motif containing protein TRIM5alpha specifically restricts HIV-1 infection at an early post-entry…
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