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TRIM5 gene

Known as: tripartite motif protein TRIM5, TRIPARTITE MOTIF-CONTAINING PROTEIN 5, TRIM5alpha 
This gene plays a role in viral infection response.
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
TRIM5 is a RING domain-E3 ubiquitin ligase that restricts infection by human immunodeficiency virus (HIV)-1 and other… Expand
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Highly Cited
2011
Highly Cited
2011
Lentiviruses such as HIV-1 traverse nuclear pore complexes (NPC) and infect terminally differentiated non-dividing cells, but how… Expand
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Highly Cited
2009
Highly Cited
2009
New World monkeys of the genus Aotus synthesize a fusion protein (AoT5Cyp) containing tripartite motif-containing 5 (TRIM5) and… Expand
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Highly Cited
2007
Highly Cited
2007
TRIM5α provides a cytoplasmic block to retroviral infection, and orthologs encoded by some primates are active against HIV. Here… Expand
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Highly Cited
2006
Highly Cited
2006
The host restriction factor TRIM5alpha mediates species-specific, early blocks to retrovirus infection; susceptibility to these… Expand
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Highly Cited
2006
Highly Cited
2006
The primate TRIM5alpha proteins have recently been defined as cellular restriction factors, preventing primate infection by… Expand
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Highly Cited
2005
Highly Cited
2005
Primate genomes encode a variety of innate immune strategies to defend themselves against retroviruses. One of these, TRIM5alpha… Expand
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Highly Cited
2004
Highly Cited
2004
In Old World primates, TRIM5-α confers a potent block to human immunodeficiency virus type 1 (HIV-1) infection that acts after… Expand
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Highly Cited
2004
Highly Cited
2004
The rhesus macaque tripartite motif containing protein TRIM5alpha specifically restricts HIV-1 infection at an early post-entry… Expand
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Highly Cited
2004
Highly Cited
2004
Murine leukemia viruses (MLVs) have been classified as N-tropic (N-MLV) or B-tropic (B-MLV), depending on their ability to infect… Expand
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