TRIM5 gene

Known as: tripartite motif protein TRIM5, TRIPARTITE MOTIF-CONTAINING PROTEIN 5, TRIM5alpha 
This gene plays a role in viral infection response.
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
TRIM5 is a RING domain-E3 ubiquitin ligase that restricts infection by human immunodeficiency virus (HIV)-1 and other… (More)
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Highly Cited
2010
Highly Cited
2010
Simian immunodeficiency viruses of sooty mangabeys (SIVsm) are the source of multiple, successful cross-species transmissions… (More)
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Highly Cited
2009
Highly Cited
2009
New World monkeys of the genus Aotus synthesize a fusion protein (AoT5Cyp) containing tripartite motif-containing 5 (TRIM5) and… (More)
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Highly Cited
2008
Highly Cited
2008
The host range of retroviruses is influenced by antiviral proteins such as TRIM5, a restriction factor that recognizes and… (More)
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Highly Cited
2008
Highly Cited
2008
The TRIM family proteins share a conserved arrangement of three adjacent domains, an N-terminal RING domain, followed by one or… (More)
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Highly Cited
2007
Highly Cited
2007
TRIM5alpha provides a cytoplasmic block to retroviral infection, and orthologs encoded by some primates are active against HIV… (More)
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Highly Cited
2007
Highly Cited
2007
OBJECTIVE In Old World monkeys, the tripartite motif 5alpha (TRIM5alpha) protein confers resistance to HIV-1 infection following… (More)
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Highly Cited
2006
Highly Cited
2006
TRIM5alpha and TRIMCyp are retroviral restriction factors that, like other members of the tripartite motif (TRIM) family, contain… (More)
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Highly Cited
2005
Highly Cited
2005
The peptidyl-prolyl isomerase cyclophilin A (CypA) embraces an exposed, proline-rich loop on HIV-1 capsid (CA) and renders… (More)
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Highly Cited
2004
Highly Cited
2004
In Old World primates, TRIM5-α confers a potent block to human immunodeficiency virus type 1 (HIV-1) infection that acts after… (More)
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