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TREX2 gene

Known as: TREX2, Three Prime Repair Exonuclease 2 Gene, 3-PRIME REPAIR EXONUCLEASE 2 
This gene is involved in DNA repair and in the maintenance of DNA integrity.
National Institutes of Health

Related topics

Related topics

5 relations
DNA RepairDNA Replication ProofreadingHAUS Augmin-Like Complex Subunit 7, humanTREX2 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer
Genetic aberrations in DNA repair genes are linked to cancer, but less is reported about epigenetic regulation of DNA repair and… 
Highly Cited
2014
Highly Cited
2014
In vitro Inactivation of Latent HSV by Targeted Mutagenesis Using an HSV-specific Homing Endonuclease
Following acute infection, herpes simplex virus (HSV) establishes latency in sensory neurons, from which it can reactivate and… 
2009
2009
TREX2 exonuclease defective cells exhibit double-strand breaks and chromosomal fragments but not Robertsonian translocations.
2009
2009
Exercise effects on tumorigenesis in a p53-deficient mouse model of breast cancer.
PURPOSE Physically active women have a reduced risk of breast cancer, but the dose of activity necessary and the role of energy… 
2008
2008
TREX1 polymorphisms associated with autoantibodies in patients with systemic lupus erythematosus
Three-prime repair exonucleases 1 and 2 (TREX1 and TREX2) play a role in the metabolism and clearance of DNA. The objective of… 
2008
2008
TREX1 polymorphisms associated with autoantibodies in patients with systemic lupus erythematosus
The information of TREX1 and TREX2 has been changed in NCBI data base (http://www.ncbi.nlm.nih.gov). Therefore, we would like to… 
2007
2007
Cisplatin depletes TREX2 and causes Robertsonian translocations as seen in TREX2 knockout cells.
Cisplatin, an anticancer drug, forms DNA interstrand cross-links (ICL) that interfere with replication, whereas TREX2 is a 3'-->5… 
2007
2007
Cisplatin Depletes TREX 2 and Causes Robertsonian Translocations as Seen in TREX 2 Knockout Cells
Cisplatin, an anticancer drug, forms DNA interstrand crosslinks (ICL) that interfere with replication, whereas TREX2 is a 3¶!5… 
2004
2004
Sequence variants in the 3'-->5' deoxyribonuclease TREX2: identification in a genetic screen and effects on catalysis by the recombinant proteins.
2002
2002
The TREX2 3′→ 5′ Exonuclease Physically Interacts with DNA Polymerase δ and Increases Its Accuracy
Proofreading function by the 3′→ 5′ exonuclease of DNA polymerase δ (pol δ) is consistent with the observation that deficiency of… 
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