FAQ

TRDMT1 gene

Known as: tRNA aspartic acid methyltransferase 1, TRDMT1, tRNA Aspartic Acid Methyltransferase 1 Gene 
This gene is involved in methylation of aspartic acid transfer RNA.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1998-2017
051019982017

Related topics

Related topics

1 relation
Methylation

Related mentions per year

Related mentions per year

1939-2018
19401960198020002020
TRDMT1 gene
Methylation

Papers overview

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Highly Cited
2012
Highly Cited
2012
Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA
The modified base 5-methylcytosine (m(5)C) is well studied in DNA, but investigations of its prevalence in cellular RNA have been… (More)
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Highly Cited
2009
Highly Cited
2009
Retrotransposon silencing and telomere integrity in somatic cells of Drosophila depends on the cytosine-5 methyltransferase DNMT2
Here we show that the cytosine-5 methyltransferase DNMT2 controls retrotransposon silencing in Drosophila somatic cells. In… (More)
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2009
2009
Azacytidine inhibits RNA methylation at DNMT2 target sites in human cancer cell lines.
The cytosine analogues azacytidine and decitabine are currently being developed as drugs for epigenetic cancer therapy. Although… (More)
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2009
2009
An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1).
BACKGROUND Spina bifida is a class of neural tube defects, which are congenital malformations of the central nervous system with… (More)
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Highly Cited
2008
Highly Cited
2008
Human DNMT2 methylates tRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism.
Although their amino acid sequences and structure closely resemble DNA methyltransferases, Dnmt2 proteins were recently shown by… (More)
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Highly Cited
2007
Highly Cited
2007
Dnmt2 functions in the cytoplasm to promote liver, brain, and retina development in zebrafish.
The roles of DNA methyltransferase-2 (DNMT2) enzymes are controversial; whether DNMT2 functions primarily as a nuclear DNA… (More)
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Highly Cited
2006
Highly Cited
2006
Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2.
The sequence and the structure of DNA methyltransferase-2 (Dnmt2) bear close affinities to authentic DNA cytosine… (More)
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Highly Cited
2003
Highly Cited
2003
Endogenous assays of DNA methyltransferases: Evidence for differential activities of DNMT1, DNMT2, and DNMT3 in mammalian cells in vivo.
While CpG methylation can be readily analyzed at the DNA sequence level in wild-type and mutant cells, the actual DNA (cytosine-5… (More)
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2002
2002
New insights into testicular germ cell tumorigenesis from gene expression profiling.
We have shown recently that about half of the human TGCTs(3) reveal DNA copy number increases affecting two distinct regions on… (More)
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Highly Cited
2001
Highly Cited
2001
Structure of human DNMT2, an enigmatic DNA methyltransferase homolog that displays denaturant-resistant binding to DNA.
DNMT2 is a human protein that displays strong sequence similarities to DNA (cytosine-5)-methyltransferases (m(5)C MTases) of both… (More)
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