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TRANCE protein

Known as: RANK Ligand, RANKL Protein, TNF Superfamily, Member 11 
A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B and… 
National Institutes of Health

Related topics

Related topics

11 relations
In BloodProcess of secretionTNFSF11 geneTNFSF11 wt Allele

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TNFSF11 protein, human

Papers overview

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2014
2014
Knockdown of PTHR1 in osteosarcoma cells decreases invasion and growth and increases tumor differentiation in vivo
Osteosarcoma (OS) is the most common cancer of bone. Parathyroid hormone (PTH) regulates calcium homeostasis and bone development… 
Review
2012
Review
2012
The development of denosumab for the treatment of diseases of bone loss and cancer‐induced bone destruction
Denosumab is a fully human monoclonal antibody against RANK ligand (RANKL), an essential cytokine for the formation, function… 
2010
2010
Combined therapy with the RANKL inhibitor RANK-Fc and rhApo2L/TRAIL/dulanermin reduces bone lesions and skeletal tumor burden in a model of breast cancer skeletal metastasis
In bone metastases, tumor cells interact with the bone microenvironment to induce osteoclastogenesis, leading to bone destruction… 
2008
2008
Expression of bone resorption regulators (RANK, RANKL, and OPG) in odontogenic tumors.
2006
2006
Evaluation of RANK/RANKL/OPG gene polymorphisms in aggressive periodontitis.
BACKGROUND AND OBJECTIVE Aggressive periodontitis (AgP) is a specific type of periodontal disease that is characterized by rapid… 
Review
2004
Review
2004
Effects of vitamin K2 on osteoporosis.
Vitamin K2 is a cofactor of gamma-carboxylase, which converts the glutamic acid (Glu) residue in osteocalcin molecules to gamma… 
Review
2001
Review
2001
Myeloma bone disease.
Highly Cited
2001
Highly Cited
2001
New insights into the regulation of cathepsin K gene expression by osteoprotegerin ligand.
Cathepsin K plays a key role in bone resorption. We provide the first evidence that osteoprotegerin ligand (OPGL), a critical pro… 
Highly Cited
2000
Highly Cited
2000
CFU-GM-derived cells form osteoclasts at a very high efficiency.
The granulocyte-macrophage progenitor (CFU-GM) is a multipotent cell that can differentiate to osteoclasts (OCLs), macrophages… 
Highly Cited
2000
Highly Cited
2000
Vitamin K(2) inhibits adipogenesis, osteoclastogenesis, and ODF/RANK ligand expression in murine bone marrow cell cultures.
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