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TRANCE protein

Known as: RANK Ligand, RANKL Protein, TNF Superfamily, Member 11 
A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B and… 
National Institutes of Health

Related topics

Related topics

11 relations
In BloodProcess of secretionTNFSF11 geneTNFSF11 wt Allele

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TNFSF11 protein, human

Papers overview

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Review
2012
Review
2012
The development of denosumab for the treatment of diseases of bone loss and cancer‐induced bone destruction
Denosumab is a fully human monoclonal antibody against RANK ligand (RANKL), an essential cytokine for the formation, function… 
2012
2012
Cell Adhesion Signaling Regulates RANK Expression in Osteoclast Precursors
Cells with monocyte/macrophage lineage expressing receptor activator of NF-κB (RANK) differentiate into osteoclasts following… 
2010
2010
Combined therapy with the RANKL inhibitor RANK-Fc and rhApo2L/TRAIL/dulanermin reduces bone lesions and skeletal tumor burden in a model of breast cancer skeletal metastasis
In bone metastases, tumor cells interact with the bone microenvironment to induce osteoclastogenesis, leading to bone destruction… 
2005
2005
Suppression of polyethylene particle-induced osteolysis by exogenous osteoprotegerin.
Alterations of the key regulators of osteoclastogenesis, receptor activator of NF-kappaB (RANK), RANK ligand (RANKL), and… 
2004
2004
Osteoclast differentiation is impaired in the absence of inhibitor of kappa B kinase alpha.
Signaling through the receptor activator of nuclear factor kappa B (RANK) is required for both osteoclast differentiation and… 
2004
2004
Expression of osteoclast differentiation factor and osteoclastogenesis inhibitory factor in rat osteoporosis induced by immunosuppressant FK506.
2004
2004
TNF receptor type 1 regulates RANK ligand expression by stromal cells and modulates osteoclastogenesis
TNFα is a major osteoclastogenic cytokine and a primary mediator of inflammatory osteoclastogenesis. We have previously shown… 
2002
2002
Histamine stimulates production of osteoclast differentiation factor/receptor activator of nuclear factor-kappaB ligand by osteoblasts.
2002
2002
Immunolocalization of osteoclast differentiation factor in rat periodontium.
2000
2000
Low calcium environment effects osteoprotegerin ligand/osteoclast differentiation factor.
In coculture with osteoblastic cell line MC3T3-E1 (E1) and mouse bone marrow cells, we reported that numbers of osteoclasts rose… 
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