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TPO Signaling Pathway
Thrombopoietin (TPO) binds to its receptor, inducing aggregation and activation. TPO signals its growth regulating effects to the cell through…
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National Institutes of Health
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CSNK2A1 wt Allele
ELK1 wt Allele
FOS wt Allele
HRAS wt Allele
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
In Newborn Mice, Tpo Signaling Is Required for Normal Megakaryocyte Proliferation, Maturation, Platelet Formation, and Platelet Survival
H. Ramsey
,
F. Ferrer-Marin
,
+5 authors
M. Sola-Visner
2014
Corpus ID: 78770332
Congenital amegakaryocytic thrombocytopenia (CAMT) is a disorder caused by c-mpl mutations that block or severely reduce…
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2012
2012
in neonatal megakaryocytes up-regulated TPO signaling through mTOR and elevated GATA-1 levels Developmental differences in megakaryocytopoiesis are associated with
L. Rimsza
,
M. Sola-Visner
,
Zhi-jian Liu
,
F. Ferrer-Marín
,
R. Gutti
,
M. Bailey
2012
Corpus ID: 87407563
Highly Cited
2011
Highly Cited
2011
Developmental differences in megakaryocytopoiesis are associated with up-regulated TPO signaling through mTOR and elevated GATA-1 levels in neonatal megakaryocytes.
Zhi-jian Liu
,
J. Italiano
,
+5 authors
M. Sola-Visner
Blood
2011
Corpus ID: 9299696
Multiple observations support the existence of developmental differences in megakaryocytopoiesis. We have previously shown that…
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2008
2008
TPO signaling: when the tyrosines go marching in(side).
R. Pozner
,
M. Schattner
Blood
2008
Corpus ID: 18940728
In this issue of Blood , Hitchcock and colleagues provide novel insights into the molecular pathways regulating TPO-mediated c…
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Highly Cited
2006
Highly Cited
2006
Increased megakaryocytopoiesis in Lyn-deficient mice
B. Lannutti
,
J. Minear
,
N. Blake
,
J. Drachman
Oncogene
2006
Corpus ID: 3184265
Previous studies in cell lines have shown Lyn kinase to be a negative regulator of thrombopoietin (TPO)-induced proliferation. To…
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Highly Cited
2005
Highly Cited
2005
Janus Kinases Affect Thrombopoietin Receptor Cell Surface Localization and Stability*
Y. Royer
,
J. Staerk
,
M. Costuleanu
,
P. Courtoy
,
S. Constantinescu
Journal of Biological Chemistry
2005
Corpus ID: 7367763
The thrombopoietin receptor (TpoR) regulates hematopoietic stem cell renewal, megakaryocyte differentiation, and platelet…
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Highly Cited
2004
Highly Cited
2004
Lnk Inhibits Tpo–mpl Signaling and Tpo-mediated Megakaryocytopoiesis
W. Tong
,
H. Lodish
Journal of Experimental Medicine
2004
Corpus ID: 17951996
Thrombopoietin (Tpo) is the primary cytokine regulating megakaryocyte development and platelet production. Tpo signaling through…
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2002
2002
Role of the thrombopoietin (TPO)/Mpl system: c‐Mpl‐like molecule/TPO signaling enhances early hematopoiesis in Xenopus laevis
M. Kakeda
,
Jun-ichi Kyuno
,
Takashi Kato
,
M. Nishikawa
,
M. Asashima
Development, Growth and Differentiation
2002
Corpus ID: 19807817
Multiple organs are induced in the primitive embryonic ectoderm excised from blastula stage Xenopus laevis embryos, under the…
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Highly Cited
1999
Highly Cited
1999
Thrombopoietin Signal Transduction Requires Functional JAK2, Not TYK2*
J. Drachman
,
K. M. Millett
,
K. Kaushansky
Journal of Biological Chemistry
1999
Corpus ID: 22971080
The Janus family of tyrosine kinases (JAKs) plays a critical role in signal transduction by members of the cytokine receptor…
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Highly Cited
1998
Highly Cited
1998
Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin.
S. Kimura
,
A. Roberts
,
D. Metcalf
,
W. Alexander
Proceedings of the National Academy of Sciences…
1998
Corpus ID: 24644892
Thrombopoietin (TPO) acts as a lineage-specific late-acting factor to stimulate megakaryocyte and platelet formation. However…
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