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TPO Signaling Pathway

Thrombopoietin (TPO) binds to its receptor, inducing aggregation and activation. TPO signals its growth regulating effects to the cell through… Expand
National Institutes of Health

Papers overview

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2014
2014
Congenital amegakaryocytic thrombocytopenia (CAMT) is a disorder caused by c-mpl mutations that block or severely reduce… Expand
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Highly Cited
2011
Highly Cited
2011
Multiple observations support the existence of developmental differences in megakaryocytopoiesis. We have previously shown that… Expand
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2008
2008
In this issue of Blood , Hitchcock and colleagues provide novel insights into the molecular pathways regulating TPO-mediated c… Expand
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2006
2006
Previous studies in cell lines have shown Lyn kinase to be a negative regulator of thrombopoietin (TPO)-induced proliferation. To… Expand
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Highly Cited
2005
Highly Cited
2005
The thrombopoietin receptor (TpoR) regulates hematopoietic stem cell renewal, megakaryocyte differentiation, and platelet… Expand
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Highly Cited
2004
Highly Cited
2004
Thrombopoietin (Tpo) is the primary cytokine regulating megakaryocyte development and platelet production. Tpo signaling through… Expand
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2002
2002
Multiple organs are induced in the primitive embryonic ectoderm excised from blastula stage Xenopus laevis embryos, under the… Expand
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Highly Cited
1999
Highly Cited
1999
The Janus family of tyrosine kinases (JAKs) plays a critical role in signal transduction by members of the cytokine receptor… Expand
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Highly Cited
1998
Highly Cited
1998
Thrombopoietin (TPO) acts as a lineage-specific late-acting factor to stimulate megakaryocyte and platelet formation. However… Expand
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