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TPO Signaling Pathway

Thrombopoietin (TPO) binds to its receptor, inducing aggregation and activation. TPO signals its growth regulating effects to the cell through… Expand
National Institutes of Health

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CSNK2A1 wt AlleleELK1 wt AlleleFOS wt AlleleHRAS wt Allele
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Papers overview

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2014
2014
In Newborn Mice, Tpo Signaling Is Required for Normal Megakaryocyte Proliferation, Maturation, Platelet Formation, and Platelet Survival
Congenital amegakaryocytic thrombocytopenia (CAMT) is a disorder caused by c-mpl mutations that block or severely reduce… Expand
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2012
2012
in neonatal megakaryocytes up-regulated TPO signaling through mTOR and elevated GATA-1 levels Developmental differences in megakaryocytopoiesis are associated with
 
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Highly Cited
2011
Highly Cited
2011
Developmental differences in megakaryocytopoiesis are associated with up-regulated TPO signaling through mTOR and elevated GATA-1 levels in neonatal megakaryocytes.
Multiple observations support the existence of developmental differences in megakaryocytopoiesis. We have previously shown that… Expand
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2008
2008
TPO signaling: when the tyrosines go marching in(side).
In this issue of Blood , Hitchcock and colleagues provide novel insights into the molecular pathways regulating TPO-mediated c… Expand
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2006
2006
Increased megakaryocytopoiesis in Lyn-deficient mice
Previous studies in cell lines have shown Lyn kinase to be a negative regulator of thrombopoietin (TPO)-induced proliferation. To… Expand
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Highly Cited
2005
Highly Cited
2005
Janus Kinases Affect Thrombopoietin Receptor Cell Surface Localization and Stability*
The thrombopoietin receptor (TpoR) regulates hematopoietic stem cell renewal, megakaryocyte differentiation, and platelet… Expand
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Highly Cited
2004
Highly Cited
2004
Lnk Inhibits Tpo–mpl Signaling and Tpo-mediated Megakaryocytopoiesis
Thrombopoietin (Tpo) is the primary cytokine regulating megakaryocyte development and platelet production. Tpo signaling through… Expand
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2002
2002
Role of the thrombopoietin (TPO)/Mpl system: c-Mpl-like molecule/TPO signaling enhances early hematopoiesis in Xenopus laevis.
Multiple organs are induced in the primitive embryonic ectoderm excised from blastula stage Xenopus laevis embryos, under the… Expand
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Highly Cited
1999
Highly Cited
1999
Thrombopoietin Signal Transduction Requires Functional JAK2, Not TYK2*
The Janus family of tyrosine kinases (JAKs) plays a critical role in signal transduction by members of the cytokine receptor… Expand
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Highly Cited
1998
Highly Cited
1998
Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin.
Thrombopoietin (TPO) acts as a lineage-specific late-acting factor to stimulate megakaryocyte and platelet formation. However… Expand
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