TPO Signaling Pathway

Thrombopoietin (TPO) binds to its receptor, inducing aggregation and activation. TPO signals its growth regulating effects to the cell through… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1995-2018
02419952018

Papers overview

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2011
2011
Multiple observations support the existence of developmental differences in megakaryocytopoiesis. We have previously shown that… (More)
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2011
2011
Multiple observations support the existence of developmental differences in megakaryocytopoiesis. We have previously shown that… (More)
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2008
2008
Thrombopoietin (TPO) and its receptor c-Mpl are the primary regulators of megakaryocytopoiesis and play a critical role in… (More)
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2006
2006
Previous studies in cell lines have shown Lyn kinase to be a negative regulator of thrombopoietin (TPO)-induced proliferation. To… (More)
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Highly Cited
2005
Highly Cited
2005
The thrombopoietin receptor (TpoR) regulates hematopoietic stem cell renewal, megakaryocyte differentiation, and platelet… (More)
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Highly Cited
2004
Highly Cited
2004
Thrombopoietin (Tpo) is the primary cytokine regulating megakaryocyte development and platelet production. Tpo signaling through… (More)
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2002
2002
Multiple organs are induced in the primitive embryonic ectoderm excised from blastula stage Xenopus laevis embryos, under the… (More)
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Highly Cited
2001
Highly Cited
2001
Thrombopoietin (TPO) is a recently characterized member of the hematopoietic growth factor family that serves as the primary… (More)
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Highly Cited
1998
Highly Cited
1998
Thrombopoietin (TPO) acts as a lineage-specific late-acting factor to stimulate megakaryocyte and platelet formation. However… (More)
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Highly Cited
1997
Highly Cited
1997
Thrombopoietin (TPO) is a recently cloned cytokine that binds to its receptor, Mpl, and promotes hematopoietic expansion and… (More)
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