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TPO Signaling Pathway

Thrombopoietin (TPO) binds to its receptor, inducing aggregation and activation. TPO signals its growth regulating effects to the cell through… 
National Institutes of Health

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CSNK2A1 wt AlleleELK1 wt AlleleFOS wt AlleleHRAS wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
In Newborn Mice, Tpo Signaling Is Required for Normal Megakaryocyte Proliferation, Maturation, Platelet Formation, and Platelet Survival
Congenital amegakaryocytic thrombocytopenia (CAMT) is a disorder caused by c-mpl mutations that block or severely reduce… 
2012
2012
in neonatal megakaryocytes up-regulated TPO signaling through mTOR and elevated GATA-1 levels Developmental differences in megakaryocytopoiesis are associated with
Highly Cited
2008
Highly Cited
2008
Roles of focal adhesion kinase (FAK) in megakaryopoiesis and platelet function: studies using a megakaryocyte lineage specific FAK knockout.
Focal adhesion kinase (FAK) plays a key role in mediating signaling downstream of integrins and growth factor receptors. In this… 
Highly Cited
2006
Highly Cited
2006
Increased megakaryocytopoiesis in Lyn-deficient mice
Previous studies in cell lines have shown Lyn kinase to be a negative regulator of thrombopoietin (TPO)-induced proliferation. To… 
Highly Cited
2005
Highly Cited
2005
Janus Kinases Affect Thrombopoietin Receptor Cell Surface Localization and Stability*
The thrombopoietin receptor (TpoR) regulates hematopoietic stem cell renewal, megakaryocyte differentiation, and platelet… 
Highly Cited
2004
Highly Cited
2004
Lnk Inhibits Tpo–mpl Signaling and Tpo-mediated Megakaryocytopoiesis
Thrombopoietin (Tpo) is the primary cytokine regulating megakaryocyte development and platelet production. Tpo signaling through… 
2002
2002
Role of the thrombopoietin (TPO)/Mpl system: c‐Mpl‐like molecule/TPO signaling enhances early hematopoiesis in Xenopus laevis
Multiple organs are induced in the primitive embryonic ectoderm excised from blastula stage Xenopus laevis embryos, under the… 
Highly Cited
2001
Highly Cited
2001
Forkhead Family Transcription Factor FKHRL1 Is Expressed in Human Megakaryocytes
FKHRL1, a member of the Forkhead transcription factor family, is one of the downstream molecules of phosphatidylinositol 3-kinase… 
Highly Cited
1997
Highly Cited
1997
Thrombopoietin signal transduction in purified murine megakaryocytes.
Thrombopoietin (TPO) is a recently cloned cytokine that binds to its receptor, Mpl, and promotes hematopoietic expansion and… 
Highly Cited
1996
Highly Cited
1996
Functional regions of the mouse thrombopoietin receptor cytoplasmic domain: evidence for a critical region which is involved in differentiation and can be complemented by erythropoietin
Thrombopoietin (TPO) is the major regulator of growth and differentiation of megakaryocytes. To identify functionally important… 
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