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TPO Signaling Pathway

Thrombopoietin (TPO) binds to its receptor, inducing aggregation and activation. TPO signals its growth regulating effects to the cell through… 
National Institutes of Health

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CSNK2A1 wt AlleleELK1 wt AlleleFOS wt AlleleHRAS wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Heterodimerization of TPO and IFNγ Impairs Human Hematopoietic Stem/Progenitor Cell Signaling and Survival in Chronic Inflammation
Thrombopoietin (TPO) is the main regulator of hematopoietic stem and progenitor cell (HSPC) self-renewal and survival. Upon… 
2017
2017
Lnk-/-genetically engineered mouse models have been instrumental in elucidating the physiologic function of Lnk
Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana Department of Microbiology and… 
2016
2016
TITLE : Calreticulin and Jak 2 as Chaperones for MPL : Insights into MPN Pathogenesis
for the 2015 ASH annual Meeting (Supported in part by DOD) In Vitro Functional Rescue of a Double MPL K39N/W272R Mutant… 
2014
2014
In Newborn Mice, Tpo Signaling Is Required for Normal Megakaryocyte Proliferation, Maturation, Platelet Formation, and Platelet Survival
Congenital amegakaryocytic thrombocytopenia (CAMT) is a disorder caused by c-mpl mutations that block or severely reduce… 
2012
2012
in neonatal megakaryocytes up-regulated TPO signaling through mTOR and elevated GATA-1 levels Developmental differences in megakaryocytopoiesis are associated with
2011
2011
Dual Role for CIB1 in Thrombopoiesis: CIB1 Suppresses Megakaryocyte Quantities but Supports Adhesion, Migration, and Proplatelet Formation
Abstract 2384 Megakaryocytes (MKs) are large polyploid cells that produce platelets through a process known as thrombopoiesis… 
Highly Cited
2006
Highly Cited
2006
Increased megakaryocytopoiesis in Lyn-deficient mice
Previous studies in cell lines have shown Lyn kinase to be a negative regulator of thrombopoietin (TPO)-induced proliferation. To… 
2002
2002
Role of the thrombopoietin (TPO)/Mpl system: c‐Mpl‐like molecule/TPO signaling enhances early hematopoiesis in Xenopus laevis
Multiple organs are induced in the primitive embryonic ectoderm excised from blastula stage Xenopus laevis embryos, under the… 
1998
1998
Aggregation of the Intracellular Domain of the Human Thrombopoietin Receptor c-MPL.
Thrombopoietin (TPO) is the major cytokine which is involved in platelet production and exerts its effects via the receptor c-MPL… 
Highly Cited
1996
Highly Cited
1996
Functional regions of the mouse thrombopoietin receptor cytoplasmic domain: evidence for a critical region which is involved in differentiation and can be complemented by erythropoietin
Thrombopoietin (TPO) is the major regulator of growth and differentiation of megakaryocytes. To identify functionally important… 
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