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TPO Signaling Pathway

Thrombopoietin (TPO) binds to its receptor, inducing aggregation and activation. TPO signals its growth regulating effects to the cell through… 
National Institutes of Health

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CSNK2A1 wt AlleleELK1 wt AlleleFOS wt AlleleHRAS wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
In Newborn Mice, Tpo Signaling Is Required for Normal Megakaryocyte Proliferation, Maturation, Platelet Formation, and Platelet Survival
Congenital amegakaryocytic thrombocytopenia (CAMT) is a disorder caused by c-mpl mutations that block or severely reduce… 
2012
2012
in neonatal megakaryocytes up-regulated TPO signaling through mTOR and elevated GATA-1 levels Developmental differences in megakaryocytopoiesis are associated with
Highly Cited
2011
Highly Cited
2011
Developmental differences in megakaryocytopoiesis are associated with up-regulated TPO signaling through mTOR and elevated GATA-1 levels in neonatal megakaryocytes.
Multiple observations support the existence of developmental differences in megakaryocytopoiesis. We have previously shown that… 
2008
2008
TPO signaling: when the tyrosines go marching in(side).
In this issue of Blood , Hitchcock and colleagues provide novel insights into the molecular pathways regulating TPO-mediated c… 
Highly Cited
2006
Highly Cited
2006
Increased megakaryocytopoiesis in Lyn-deficient mice
Previous studies in cell lines have shown Lyn kinase to be a negative regulator of thrombopoietin (TPO)-induced proliferation. To… 
Highly Cited
2005
Highly Cited
2005
Janus Kinases Affect Thrombopoietin Receptor Cell Surface Localization and Stability*
The thrombopoietin receptor (TpoR) regulates hematopoietic stem cell renewal, megakaryocyte differentiation, and platelet… 
Highly Cited
2004
Highly Cited
2004
Lnk Inhibits Tpo–mpl Signaling and Tpo-mediated Megakaryocytopoiesis
Thrombopoietin (Tpo) is the primary cytokine regulating megakaryocyte development and platelet production. Tpo signaling through… 
2002
2002
Role of the thrombopoietin (TPO)/Mpl system: c‐Mpl‐like molecule/TPO signaling enhances early hematopoiesis in Xenopus laevis
Multiple organs are induced in the primitive embryonic ectoderm excised from blastula stage Xenopus laevis embryos, under the… 
Highly Cited
1999
Highly Cited
1999
Thrombopoietin Signal Transduction Requires Functional JAK2, Not TYK2*
The Janus family of tyrosine kinases (JAKs) plays a critical role in signal transduction by members of the cytokine receptor… 
Highly Cited
1998
Highly Cited
1998
Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin.
Thrombopoietin (TPO) acts as a lineage-specific late-acting factor to stimulate megakaryocyte and platelet formation. However… 
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