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TPO Signaling Pathway

Thrombopoietin (TPO) binds to its receptor, inducing aggregation and activation. TPO signals its growth regulating effects to the cell through… 
National Institutes of Health

Papers overview

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2014
2014
Congenital amegakaryocytic thrombocytopenia (CAMT) is a disorder caused by c-mpl mutations that block or severely reduce… 
Highly Cited
2011
Highly Cited
2011
Multiple observations support the existence of developmental differences in megakaryocytopoiesis. We have previously shown that… 
2008
2008
In this issue of Blood , Hitchcock and colleagues provide novel insights into the molecular pathways regulating TPO-mediated c… 
Highly Cited
2006
Highly Cited
2006
Previous studies in cell lines have shown Lyn kinase to be a negative regulator of thrombopoietin (TPO)-induced proliferation. To… 
Highly Cited
2005
Highly Cited
2005
The thrombopoietin receptor (TpoR) regulates hematopoietic stem cell renewal, megakaryocyte differentiation, and platelet… 
Highly Cited
2004
Highly Cited
2004
Thrombopoietin (Tpo) is the primary cytokine regulating megakaryocyte development and platelet production. Tpo signaling through… 
2002
2002
Multiple organs are induced in the primitive embryonic ectoderm excised from blastula stage Xenopus laevis embryos, under the… 
Highly Cited
1999
Highly Cited
1999
The Janus family of tyrosine kinases (JAKs) plays a critical role in signal transduction by members of the cytokine receptor… 
Highly Cited
1998
Highly Cited
1998
Thrombopoietin (TPO) acts as a lineage-specific late-acting factor to stimulate megakaryocyte and platelet formation. However…