TP-434
National Institutes of Health
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Eravacycline (7-fluoro-9-pyrrolidinoacetamido-6-demethyl-6-deoxytetracycline or TP-434) is a novel, fully synthetic broad…
A convergent total synthesis platform has enabled diverse modifications of the tetracycline chemical space that were previously…
Body: Background: Mtb is the leading cause of death from infection. Essential enzymes that have not yet been targeted in Mtb…
Volume 56, no. 5, p. [2559–2564][1], 2012. Page 2561: In [Table 1][2], the labeling of the columns should be reversed. The table…
Despite the scientific and technological breakthroughs that have graced the last century, the path to bringing a drug to the…
Time to defervescence is displayed graphically by using Kaplan Meier methodology for the MITT population below. 88.9%, 96.7%, and…
0.2% Carrageenen intravenously (IV) to establish pyelonephritis. TP-434 was administered IV 12 and 24 hours post-infection and 36…
Results: The metabolic stability of TP-434 was high, with 103.2%, 95%, 94.0%, and 85.3% remaining after 4 hours incubation with…
The 50th annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), held in Boston, included topics…