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TOP2B protein, human

Known as: EC 5.99.1.3, topoisomerase (DNA) II beta 180kDa protein, human, TOP2B 
DNA topoisomerase 2-beta (1626 aa, ~183 kDa) is encoded by the human TOP2B gene. This protein plays a role in DNA relaxation.
National Institutes of Health

Related topics

Related topics

13 relations
5-chloroquinoxaline-2-sulfanilamideATPase DomainCell NucleusChromosome Condensation

Broader (1)

DNA topoisomerase II beta

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Investigation of Structure-Activity Relationships of Dexrazoxane Analogs Reveals Topoisomerase IIβ Interaction as a Prerequisite for Effective Protection against Anthracycline Cardiotoxicity
Bisdioxopiperazine agent dexrazoxane (ICRF-187) has been the only effective and approved drug for prevention of chronic… 
2020
2020
Transcription of carbonyl reductase 1 is regulated by DNA topoisomerase II beta
DNA topoisomerase II beta (TOP2B) has a role in transcriptional regulation. Here, to further investigate transcriptional… 
2019
2019
Neonatal murine engineered cardiac tissue toxicology model: Impact of dexrazoxane on doxorubicin induced injury.
2019
2019
Clarifying the Mechanism of Copper(II) α-(N)-Heterocyclic Thiosemicarbazone Complexes on DNA Topoisomerase IIα and IIβ.
Cells utilize type II topoisomerases to alleviate topological strain in DNA associated with replication and transcription and to… 
2015
2015
Differential Targeting of Human Topoisomerase II Isoforms with Small Molecules.
The TOP2 poison etoposide has been implicated in the generation of secondary malignancies during cancer treatment. Structural… 
2014
2014
Relation of ETS transcription factor family member ERG, androgen receptor and topoisomerase 2β expression to TMPRSS2-ERG fusion status in prostate cancer.
Fusion of TMPRSS2 with ERG in prostate cells is determined by double-strand DNA breaks induced by androgen signaling and… 
2014
2014
STUDY OF MOLECULAR MECHANISMS INVOLVED IN CARDIOPROTECTIVE ACTION OF DEXRAZOXANE AGAINST ANTHRACYCLINE CARDIOTOXICITY IN RABBITS
So far dexrazoxane (DEX) is the only drug approved for prevention of chronic anthracycline (ANT) cardiotoxicity. However… 
Review
2013
Review
2013
“Breaking news” from spermatids
During the haploid phase of spermatogenesis, spermatids undergo a complex remodeling of the paternal genome involving the finely… 
2013
2013
Relation of ETS transcription factor family member ERG, androgen receptor and topoisomerase 2β expression to TMPRSS2-ERG fusion status in prostate cancer.
Fusion of TMPRSS2 with ERG in prostate cells is determined by double-strand DNA breaks induced by androgen signaling and… 
2002
2002
Characterization of the human topoisomerase IIbeta (TOP2B) promoter activity: essential roles of the nuclear factor-Y (NF-Y)- and specificity protein-1 (Sp1)-binding sites.
Eukaryotic topoisomerase II (topo II) catalyses topological genomic changes essential for chromosome segregation, chromatin… 
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