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Exploiting genotyping, DNA sequencing, imputation and trans-ancestral mapping, we used Bayesian and frequentist approaches to… Expand BackgroundDespite intensive investigation the mechanism by which HIV-1 reaches the host cell nucleus is unknown. TNPO3, a… Expand The HIV-1 genome enters cells inside a shell comprised of capsid (CA) protein. Variation in CA sequence alters HIV-1 infectivity… Expand HIV-1 infection of macrophages plays a key role in viral pathogenesis and progression to AIDS. Polyinosine-polycytidylic acid… Expand ABSTRACT TNPO3 is a nuclear importer required for HIV-1 infection. Here, we show that depletion of TNPO3 leads to an HIV-1 block… Expand The HIV/AIDS pandemic is a major global health threat and understanding the detailed molecular mechanisms of HIV replication is… Expand BackgroundHIV-1 infects non-dividing cells. This implies that the virus traverses the nuclear pore before it integrates into… Expand ABSTRACT Recent genome-wide screens have highlighted an important role for transportin 3 in human immunodeficiency virus type 1… Expand OBJECTIVE
Interferon regulatory factor 5, an established susceptibility factor for systemic lupus erythematosus (SLE), plays a… Expand HIV-1 exploits multiple host proteins during infection. We performed a large-scale small interfering RNA screen to identify host… Expand