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TNFerade

National Institutes of Health

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adenovirus 5-tumor necrosis factor alpha

Papers overview

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2009
2009
Surgical resection after TNFerade therapy for locally advanced pancreatic cancer.
CONTEXT Treatment of pancreatic cancer remains a major oncological challenge and survival is dismal. Most patients, present with… 
2009
2009
Multicenter randomized controlled phase III clinical trial using TNFerade (TNF) with chemoradiation (CRT) in patients with locally advanced pancreatic cancer (LAPC): Interim analysis (IA) of overall…
4605 Intro: Local control of LAPC with CRT has historically demonstrated survival benefit vs. RT alone. TNF is a nonreplicating… 
2008
2008
A phase I dose escalation study of Ad GV.EGR.TNF.11D (TNFerade) with concurrent chemoradiotherapy in patients with recurrent head and neck cancer (HNC)
6067 Background: The prognosis for patients with locoregionally recurrent HNC remains poor. Re-irradiation with concomitant… 
2007
2007
A pilot study of local injection of TNFerade biologic in addition to neo-adjuvant chemoradiation for the treatment of primary and recurrent rectal cancer
14585 Background: Rectal cancer presents unique therapeutic considerations due to competing concerns regarding sphincter… 
2005
2005
Updated response and survival data for TNFerade combined with chemoradiation in the treatment of locally advanced pancreatic cancer (LAPC)
4097 Background: TNFerade is a replication-deficient adenovector containing the human TNF-α gene regulated by a chemoradiation… 
2004
2004
Safety and efficacy of TNFerade in unresectable, locally advanced pancreatic cancer (LAPC): Results of the first three cohorts of a dose-escalating study
3038 Background: TNFerade is a replication-deficient adenovector containing the TNF-α gene regulated by a radiation-inducible… 
Review
2004
Review
2004
TNFerade to the rescue? Guidelines for evaluating phase I cancer gene transfer trials.
In this issue of the Journal of Clinical Oncology, Senzer et al [1] describe the results of their phase 1 gene transfer trial of… 
2004
2004
Safety and efficacy of TNFerade in unresectable, locally advanced pancreatic cancer (LAPC): Results of the first three cohorts of a dose-escalating study.
3038 Background: TNFerade is a replication-deficient adenovector containing the TNF-α gene regulated by a radiation-inducible… 
Review
2003
Review
2003
Technology evaluation: TNFerade, GenVec.
TNFerade is a new gene therapy drug under development by GenVec that employs a replication-deficient adenovector carrying the… 
2001
2001
Phase I dose-escalation study of tumor necrosis factor-α gene transfer with radiation therapy for advanced solid tumors
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