TNF receptor-associated factor 3

Known as: CRAF1 Protein, LAP-1 Protein, LMP1-associated protein 1 
A signal transducing tumor necrosis factor receptor associated factor that is involved in regulation of NF-KAPPA B signaling and activation of… (More)
National Institutes of Health

Related topics

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20 relations
B-Cell Immune Response PathwayCD40L Signaling PathwayIn BloodPositive Regulation of Apoptosis
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Papers overview

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Highly Cited
2010
Highly Cited
2010
Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis.
Tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) functions downstream of multiple TNF receptors and receptors… (More)
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Highly Cited
2007
Highly Cited
2007
Tumor necrosis factor receptor-associated factor 3 is a critical regulator of B cell homeostasis in secondary lymphoid organs.
Tumor necrosis factor receptor-associated factor 3 (TRAF3) is an adaptor protein that directly binds to a number of receptors of… (More)
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Highly Cited
2006
Highly Cited
2006
Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6
Toll-like receptors (TLRs) are activated by pathogen-associated molecular patterns to induce innate immune responses and… (More)
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Highly Cited
2006
Highly Cited
2006
Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response
Type I interferon (IFN) production is a critical component of the innate defence against viral infections. Viral products induce… (More)
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Highly Cited
2005
Highly Cited
2005
TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-kappaB pathway by TRAF-binding TNFRs.
TNF family members and their receptors contribute to increased gene expression for inflammatory processes and intracellular… (More)
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Highly Cited
2003
Highly Cited
2003
Resistin promotes endothelial cell activation: further evidence of adipokine-endothelial interaction.
BACKGROUND Adipocyte-derived hormones may represent a mechanism linking insulin resistance to cardiovascular disease. In the… (More)
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Highly Cited
2000
Highly Cited
2000
TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappa B, elk-1, c-Jun N-terminal kinase, and p38 mitogen…
BCMA (B cell maturation) is a nonglycosylated integral membrane type I protein that is preferentially expressed in mature B… (More)
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Highly Cited
1997
Highly Cited
1997
Epstein – Barr virus-encoded LMP1 and CD40 mediate IL-6 production in epithelial cells via an NF-κB pathway involving TNF receptor-associated factors
Expression of the Epstein – Barr virus (EBV) transforming LMP1 in B cells activates the transcription factor NF-κB and induces… (More)
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Review
1996
Review
1996
Transducers of life and death: TNF receptor superfamily and associated proteins.
Signal transduction pathways which are initiated by members of the TNF superfamily utilize receptors which are devoid of… (More)
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Highly Cited
1996
Highly Cited
1996
TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling.
Signals emanating from CD40 play crucial roles in B-cell function. To identify molecules that transduce CD40 signalings, we have… (More)
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