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X-linked spinal and bulbar muscular atrophy (SBMA) is characterized by adult-onset muscle weakness and lower motor neuron… Expand Idiopathic pulmonary arterial hypertension (PAH) is a life-threatening condition characterized by pulmonary arteriolar remodeling… Expand Many actin-binding proteins have been shown to possess multiple activities to regulate filament dynamics. Tropomodulins (Tmod1–4… Expand Recent advances in cancer therapeutics stress the need for a better understanding of the molecular mechanisms driving tumor… Expand Recent studies have identified stem cells in brain cancer. However, their relationship to normal CNS progenitors, including… Expand Although the role of the actin cytoskeleton in morphogenesis of polarized epithelial sheets is generally accepted as centrally… Expand Regulation of the actin cytoskeleton by filament capping proteins is critical to myriad dynamic cellular functions. The ability… Expand Conventional approaches to produce transgenic mice recurrently yield unpredictable patterns and levels of transgene expression, a… Expand BackgroundLong terminal repeat (LTR) retrotransposons constitute a major fraction of the genomes of higher plants. For example… Expand JCV is a papovavirus which is widespread in the human population. The prototype Mad-1 variant of JCV induces a fatal… Expand