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TMED10 gene

Known as: TRANSMEMBRANE TRAFFICKING PROTEIN, 21-KD, P24(DELTA), p24delta1 
National Institutes of Health

Papers overview

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2019
2019
TMP21 regulates autophagy by modulating ROS production and mTOR activation.
2017
2017
A Novel Alzheimer-Associated SNP in Tmp21 Increases Amyloidogenesis
Recent studies suggest that TMP21 is a selective modulator of γ-secretase and its dysregulation affects APP processing, leading… 
2015
2015
TMP21 modulates cell growth in papillary thyroid cancer cells by inducing autophagy through activation of the AMPK/mTOR pathway.
OBJECTIVE To investigate the role of transmembrane protein (TMP) 21 in human thyroid cancer. METHODS The recombinant expression… 
2014
2014
Identification of Pre-Erythrocytic Malaria Antigens That Target Hepatocytes for Killing In Vivo and Contribute to Protection Elicited by Whole-Parasite Vaccination
Pre-erythrocytic malaria vaccines, including those based on whole-parasite approaches, have shown protective efficacy in animal… 
Review
2012
Review
2012
The role of TMP21 in trafficking and amyloid-β precursor protein (APP) processing in Alzheimer's disease.
Alzheimer's Disease (AD) is the most common neurodegenerative disorder leading to dementia. A major neuropathological hallmark of… 
2011
2011
p23/Tmp21 Associates with Protein Kinase Cδ (PKCδ) and Modulates Its Apoptotic Function*
There is emerging evidence that C1 domains, motifs originally identified in PKC isozymes and responsible for binding of phorbol… 
2011
2011
Tmp21, a novel MHC-I interacting protein, preferentially binds to Β2-microglobulin-free MHC-I heavy chains.
MHC-I molecules play a critical role in immune surveillance against viruses by presenting peptides to cytotoxic T lymphocytes… 
2008
2008
TMP21 degradation is mediated by the ubiquitin‐proteasome pathway
The presenilin‐associated complex regulates two independent intramembranous cleavage activities, i.e. γ‐secretase and ε‐secretase… 
2008
2008
TMP21 regulates Abeta production but does not affect caspase-3, p53, and neprilysin.
1999
1999
A comparative study of rat and human Tmp21 (p23) reveals the pseudogene-like features of human Tmp21-II.
Tmp21 (p23) is involved in biosynthetic transport from the endoplasmic reticulum to the Golgi complex. We have recently… 
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