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TLE4 gene

Known as: E(spI), TLE4, transducin like enhancer of split 4 
This gene plays a role in Notch and Wnt signaling pathways and transcriptional repression.
National Institutes of Health

Related topics

Related topics

9 relations
Signal TransductionTLE1 geneTLE2 geneTLE3 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
TLE4 promotes colorectal cancer progression through activation of JNK/c-Jun signaling pathway
The Groucho transcriptional co-repressor TLE4 protein has been shown to be a tumor suppressor in a subset of acute myeloid… 
Highly Cited
2011
Highly Cited
2011
miR-93 suppresses proliferation and colony formation of human colon cancer stem cells.
AIM To identify differentially expressed microRNAs (miRNAs) in human colon cancer stem cells (SW1116csc) and study their function… 
Highly Cited
2008
Highly Cited
2008
Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperates with AML1-ETO to affect myeloid cell proliferation and survival.
Deletions on chromosome 9q are seen in a subset of acute myeloid leukemia (AML) cases and are specifically associated with t(8;21… 
Highly Cited
2007
Highly Cited
2007
FoxD3 and Grg4 Physically Interact to Repress Transcription and Induce Mesoderm in Xenopus*
FoxD3 is a forkhead-related transcriptional regulator that is essential for multiple developmental processes in the vertebrate… 
Highly Cited
2007
Highly Cited
2007
The roles of Groucho/Tle in left-right asymmetry and Kupffer's vesicle organogenesis.
2006
2006
An Inducible Mouse Model for PAX2-Dependent Glomerular Disease: Insights into a Complex Pathogenesis
Highly Cited
2004
Highly Cited
2004
Corecruitment of the Grg4 repressor by PU.1 is critical for Pax5‐mediated repression of B‐cell‐specific genes
PU.1 and Pax5 are important regulators of immunoglobulin heavy‐chain (IgH) gene expression in B lineage cells. We have previously… 
2002
2002
A new Groucho TLE4 protein may regulate the repressive activity of Pax5 in human B lymphocytes
During mouse B‐cell development, Pax5 is an essential transcription factor that acts as an activator of B‐cell‐specific genes and… 
Highly Cited
2000
Highly Cited
2000
Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family
Pax5 (BSAP) functions as both a transcriptional activator and repressor during midbrain patterning, B‐cell development and… 
Highly Cited
1996
Highly Cited
1996
Transcripts of Grg4, a murine groucho-related gene, are detected in adjacent tissues to other murine neurogenic gene homologues during embryonic development
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