TK Gene

Known as: Thymidine Kinase Gene 
The TK Gene encodes thymidine kinase, a transferase class pyrimidine salvage enzyme that catalyzes ATP-dependent phosphorylation of thymine… (More)
National Institutes of Health

Papers overview

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2008
2008
Targeted delivery of a suicide gene to human colorectal tumors by a conditionally replicating vaccinia virus
We have generated a thymidine kinase gene-deleted vaccinia virus (VV) (Copenhagen strain) that expressed the fusion suicide gene… (More)
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Highly Cited
2004
Highly Cited
2004
Cloning of the koi herpesvirus (KHV) gene encoding thymidine kinase and its use for a highly sensitive PCR based diagnosis
Outbreaks with mass mortality among common carp Cyprinus carpio carpio and koi Cyprinus carpio koi have occurred worldwide since… (More)
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Highly Cited
2002
Highly Cited
2002
Mitochondrial DNA depletion: mutations in thymidine kinase gene with myopathy and SMA.
BACKGROUND The mitochondrial DNA (mtDNA) depletion syndrome (MDS) is an autosomal recessive disorder of early childhood… (More)
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Highly Cited
2001
Highly Cited
2001
An adenovirus with enhanced infectivity mediates molecular chemotherapy of ovarian cancer cells and allows imaging of gene expression.
The adenovirus (Ad) is a useful vector for cancer gene therapy due to its unparalleled gene transfer efficiency to dividing and… (More)
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Highly Cited
1991
Highly Cited
1991
Selective killing of glioma cells in culture and in vivo by retrovirus transfer of the herpes simplex virus thymidine kinase gene.
The thymidine kinase gene (tk) of herpes simplex type 1 virus (HSV-1) was inserted into a retroviral vector under the… (More)
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Highly Cited
1991
Highly Cited
1991
Dominant positive and negative selection using a hygromycin phosphotransferase-thymidine kinase fusion gene.
The hygromycin phosphotransferase gene was fused in-frame with the herpes simplex virus type 1 thymidine kinase gene. The… (More)
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Highly Cited
1988
Highly Cited
1988
Dependence of intrachromosomal recombination in mammalian cells on uninterrupted homology.
Recombination between a 360-base-pair (bp) segment of a wild-type thymidine kinase gene (tk) from each of three different strains… (More)
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Highly Cited
1985
Highly Cited
1985
Insertion mutagenesis to increase secondary structure within the 5′ noncoding region of a eukaryotic mRNA reduces translational efficiency
The thymidine kinase gene of herpes simplex virus 1 was mutated by inserting oligodeoxynucleotide linkers into the region of the… (More)
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1985
1985
Isomerization of herpes simplex virus 1 genome: identification of the cis-acting and recombination sites within the domain of the a sequence.
Previous studies have shown that the a sequence located at the termini and at the junction between the L and S components is the… (More)
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1983
1983
A small region of the mouse mammary tumor virus long terminal repeat confers glucocorticoid hormone regulation on a linked heterologous gene.
Expression of mouse mammary tumor virus (MMTV) proviruses is transcriptionally regulated by glucocorticoid hormones. We have… (More)
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