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TK Gene

Known as: Thymidine Kinase Gene 
The TK Gene encodes thymidine kinase, a transferase class pyrimidine salvage enzyme that catalyzes ATP-dependent phosphorylation of thymine… Expand
National Institutes of Health

Papers overview

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Highly Cited
1989
Highly Cited
1989
Germline transmission of exogenous genes in the chicken.
Difficulties associated with in vitro manipulation and culture of the early chicken embryo have restricted generation of… Expand
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Highly Cited
1985
Highly Cited
1985
Insertion mutagenesis to increase secondary structure within the 5′ noncoding region of a eukaryotic mRNA reduces translational efficiency
The thymidine kinase gene of herpes simplex virus 1 was mutated by inserting oligodeoxynucleotide linkers into the region of the… Expand
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Highly Cited
1984
Highly Cited
1984
Expression of rabies virus glycoprotein from a recombinant vaccinia virus
Rabies is one of the oldest diseases known to man, but its successful control has remained elusive. Although effective vaccines… Expand
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Highly Cited
1984
Highly Cited
1984
Human thymidine kinase gene: molecular cloning and nucleotide sequence of a cDNA expressible in mammalian cells.
A cDNA containing the entire coding region of the human thymidine kinase gene has been molecularly cloned. The cDNA is under the… Expand
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Highly Cited
1982
Highly Cited
1982
Construction of poxviruses as cloning vectors: insertion of the thymidine kinase gene from herpes simplex virus into the DNA of infectious vaccinia virus.
We have constructed recombinant vaccinia viruses containing the thymidine kinase gene from herpes simplex virus. The gene was… Expand
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Highly Cited
1982
Highly Cited
1982
In vitro methylation of the hamster adenine phosphoribosyltransferase gene inhibits its expression in mouse L cells.
The effect of DNA methylation on the expression of the hamster adenine phosphoribosyltransferase (aprt) gene in mouse cells has… Expand
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Highly Cited
1982
Highly Cited
1982
A synthetic heat‐shock promoter element confers heat‐inducibility on the herpes simplex virus thymidine kinase gene.
Previous deletion analysis of the Drosophila hsp70 heat‐shock promoter has identified a sequence upstream of the TATA box that is… Expand
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Highly Cited
1981
Highly Cited
1981
A new dominant hybrid selective marker for higher eukaryotic cells.
Abstract A new dominant hybrid genetic marker, suitable for selection in higher eukaryotic cells, has been obtained by linking… Expand
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Highly Cited
1981
Highly Cited
1981
Nucleotide sequence of the thymidine kinase gene of herpes simplex virus type 1.
We have determined the complete nucleotide sequence of the thymidine kinase (ATP:thymidine 5' phosphotransferase, EC 2.7.1.21… Expand
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Highly Cited
1980
Highly Cited
1980
Excretion of hepatitis B surface antigen particles from mouse cells transformed with cloned viral DNA.
A plasmid containing two cloned hepatitis B virus genomes in a tandem head-to-tail arrangement has been introduced into mouse… Expand
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