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TK Gene

Known as: Thymidine Kinase Gene 
The TK Gene encodes thymidine kinase, a transferase class pyrimidine salvage enzyme that catalyzes ATP-dependent phosphorylation of thymine… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1997
Highly Cited
1997
Transcriptional targeting of herpes simplex virus for cell-specific replication
Tissue- or cell-specific targeting of vectors is critical to the success of gene therapy. We describe a novel approach to virus… 
Highly Cited
1996
Highly Cited
1996
Gene therapy for α‐fetoprotein‐producing human hepatoma cells by adenovirus‐mediated transfer of the herpes simplex virus thymidine kinase gene
We have developed a recombinant replication‐defective adenovirus containing human α‐fetoprotein (AFP) promoter/enhancer to direct… 
Highly Cited
1988
Highly Cited
1988
Delineation of the viral products of recombination in vaccinia virus-infected cells
Plasmids containing the vaccinia virus thymidine kinase gene, its flanking DNA sequences, and the Escherichia coli beta… 
Highly Cited
1986
Highly Cited
1986
Identification by antibody to a synthetic peptide of a protein specified by a diploid gene located in the terminal repeats of the L component of herpes simplex virus genome
In the course of studies on the a sequences located at the termini of and at the junction between the L and S components of… 
Highly Cited
1985
Highly Cited
1985
Expression of Sindbis virus structural proteins via recombinant vaccinia virus: synthesis, processing, and incorporation into mature Sindbis virions
We have obtained a vaccinia virus recombinant which contains a complete cDNA copy of the 26S RNA of Sindbis virus within the… 
Highly Cited
1985
Highly Cited
1985
Isomerization of herpes simplex virus 1 genome: identification of the cis-acting and recombination sites within the domain of the a sequence
Highly Cited
1984
Highly Cited
1984
Analysis of DNA sequences which regulate the transcription of a herpes simplex virus immediate early gene
The locations and functions of DNA sequences involved in transcription of the gene encoding herpes simplex virus type 1 immediate… 
Highly Cited
1984
Highly Cited
1984
Expression of hepatitis B virus S gene by herpes simplex virus type 1 vectors carrying alpha- and beta-regulated gene chimeras.
The domain of the hepatitis B virus (HBV) S gene specifying the HBV surface antigen (HBsAg) and comprising 25 base pairs of the 5… 
Highly Cited
1983
Highly Cited
1983
Bovine papilloma virus contains an activator of gene expression at the distal end of the early transcription unit
Bovine papilloma virus (BPV) contains a cis-acting DNA element which can enhance transcription of distal promoters. Utilizing… 
Highly Cited
1983
Highly Cited
1983
Nucleotide sequence of the herpes simplex virus type 2 (HSV-2) thymidine kinase gene and predicted amino acid sequence of thymidine kinase polypeptide and its comparison with the HSV-1 thymidine…
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