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Flaviviridae :T he Viruses and Their Replication
The present research attacked the Flavivirus infection through two mechanisms: Membrane Reorganization and the Compartmentalization and Assembly and Release of Particles from Flaviv virus-infected Cells and Host Resistance to Flaviviral Infection. Expand
Complete Replication of Hepatitis C Virus in Cell Culture
A full-length HCV genome that replicates and produces virus particles that are infectious in cell culture (HCVcc) is described, suggesting that this in vitro system will aid in the search for improved antiviral compounds. Expand
Flavivirus genome organization, expression, and replication.
Efficient initiation of HCV RNA replication in cell culture.
This work establishes a robust, cell-based system for genetic and functional analyses of HCV replication and identifies multiple independent adaptive mutations that cluster in the HCV nonstructural protein NS5A and confer increased replicative ability in vitro. Expand
Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry
Using an iterative expression cloning approach, claudin-1 (CLDN1), a tight junction component that is highly expressed in the liver, is identified as essential for HCV entry and a new target for antiviral drug development. Expand
Identification of microRNAs of the herpesvirus family
To identify other miRNA genes in pathogenic viruses, a new miRNA gene prediction method with small-RNA cloning from several virus-infected cell types was combined and predicted miRNAs in several large DNA viruses. Expand
Corrigendum: A diverse range of gene products are effectors of the type I interferon antiviral response
This corrects the article to show that the Higgs boson genome is a “spatially aggregated “vessel” rather than an “ aggregating “ nucleus”, which is more closely related to DNA than to RNA. Expand
Interferon-stimulated genes: a complex web of host defenses.
This review begins by introducing interferon (IFN) and the JAK-STAT signaling pathway to highlight features that impact ISG production and describes ways in which ISGs both enhance innate pathogen-sensing capabilities and negatively regulate signaling through the Jak-STAT pathway. Expand
Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles
- M. Hsu, J. Zhang, +4 authors J. McKeating
- Medicine, Biology
- Proceedings of the National Academy of Sciences…
- 21 May 2003
HIV–HCV pseudotype infectivity was inhibited by a recombinant soluble form of CD81 and a mAb specific for CD81, suggesting that CD81 may be a component of a receptor complex. Expand
Human occludin is a hepatitis C virus entry factor required for infection of mouse cells
It is shown that human occludin (OCLN) is an essential HCV cell entry factor that is able to render murine cells infectable with HCVpp and the identification of OCLN as a new HCV entry factor further highlights the importance of the tight junction complex in the viral entry process. Expand