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Complete Replication of Hepatitis C Virus in Cell Culture
Many aspects of the hepatitis C virus (HCV) life cycle have not been reproduced in cell culture, which has slowed research progress on this important human pathogen. Here, we describe a full-lengthExpand
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Flaviviridae :T he Viruses and Their Replication
FLAVIVIRUSES 1103 Background and Classification 1103 Structure and Physical Properties of the Virion 1104 Binding and Entry 1105 Genome Structure 1106 Translation and Proteolytic Processing 1107Expand
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Flavivirus genome organization, expression, and replication.
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Efficient initiation of HCV RNA replication in cell culture.
Hepatitis C virus (HCV) infection is a global health problem affecting an estimated 170 million individuals worldwide. We report the identification of multiple independent adaptive mutations thatExpand
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Corrigendum: A diverse range of gene products are effectors of the type I interferon antiviral response
This corrects the article DOI: 10.1038/nature09907
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Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry
Hepatitis C virus (HCV) is a leading cause of cirrhosis and liver cancer worldwide. A better understanding of the viral life cycle, including the mechanisms of entry into host cells, is needed toExpand
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Interferon-stimulated genes: a complex web of host defenses.
Interferon-stimulated gene (ISG) products take on a number of diverse roles. Collectively, they are highly effective at resisting and controlling pathogens. In this review, we begin by introducingExpand
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Identification of microRNAs of the herpesvirus family
Epstein-Barr virus (EBV or HHV4), a member of the human herpesvirus (HHV) family, has recently been shown to encode microRNAs (miRNAs). In contrast to most eukaryotic miRNAs, these viral miRNAs doExpand
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Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles
HIV pseudotypes bearing native hepatitis C virus (HCV) glycoproteins (strain H and Con1) are infectious for the human hepatoma cell lines Huh-7 and PLC/PR5. Infectivity depends on coexpression ofExpand
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Human occludin is a hepatitis C virus entry factor required for infection of mouse cells
Hepatitis C virus (HCV) is a leading cause of liver disease worldwide. The development of much needed specific antiviral therapies and an effective vaccine has been hampered by the lack of aExpand
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