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Complete Replication of Hepatitis C Virus in Cell Culture
Many aspects of the hepatitis C virus (HCV) life cycle have not been reproduced in cell culture, which has slowed research progress on this important human pathogen. Here, we describe a full-length… Expand
Flaviviridae :T he Viruses and Their Replication
FLAVIVIRUSES 1103 Background and Classification 1103 Structure and Physical Properties of the Virion 1104 Binding and Entry 1105 Genome Structure 1106 Translation and Proteolytic Processing 1107… Expand
Flavivirus genome organization, expression, and replication.
Efficient initiation of HCV RNA replication in cell culture.
Hepatitis C virus (HCV) infection is a global health problem affecting an estimated 170 million individuals worldwide. We report the identification of multiple independent adaptive mutations that… Expand
Corrigendum: A diverse range of gene products are effectors of the type I interferon antiviral response
This corrects the article DOI: 10.1038/nature09907
Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry
Hepatitis C virus (HCV) is a leading cause of cirrhosis and liver cancer worldwide. A better understanding of the viral life cycle, including the mechanisms of entry into host cells, is needed to… Expand
Interferon-stimulated genes: a complex web of host defenses.
- William M. Schneider, Meike Dittmann Chevillotte, C. Rice
- Biology, Medicine
- Annual review of immunology
- 21 March 2014
Interferon-stimulated gene (ISG) products take on a number of diverse roles. Collectively, they are highly effective at resisting and controlling pathogens. In this review, we begin by introducing… Expand
Identification of microRNAs of the herpesvirus family
Epstein-Barr virus (EBV or HHV4), a member of the human herpesvirus (HHV) family, has recently been shown to encode microRNAs (miRNAs). In contrast to most eukaryotic miRNAs, these viral miRNAs do… Expand
Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles
- M. Hsu, J. Zhang, +4 authors J. McKeating
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 21 May 2003
HIV pseudotypes bearing native hepatitis C virus (HCV) glycoproteins (strain H and Con1) are infectious for the human hepatoma cell lines Huh-7 and PLC/PR5. Infectivity depends on coexpression of… Expand
Human occludin is a hepatitis C virus entry factor required for infection of mouse cells
Hepatitis C virus (HCV) is a leading cause of liver disease worldwide. The development of much needed specific antiviral therapies and an effective vaccine has been hampered by the lack of a… Expand