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TJ-M2010-5

 
National Institutes of Health

Papers overview

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2019
2019
Short-term use of MyD88 inhibitor TJ-M2010-5 prevents d-galactosamine/lipopolysaccharide-induced acute liver injury in mice.
Excessive activation of the TLR/MyD88 signaling pathway contributes to several inflammation-related diseases. Previously, our… Expand
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2019
2019
Modulating the conformation of the TIR domain by a neoteric MyD88 inhibitor leads to the separation of GVHD from GVT
Abstract Graft-versus-host disease (GVHD) remains the least curable complication after allogeneic bone marrow transplantation… Expand
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2018
2018
A Novel Inhibitor of Homodimerization Targeting MyD88 Ameliorates Renal Interstitial Fibrosis by Counteracting TGF-β1-Induced EMT in Vivo and in Vitro
Background/Aims: The TLR/MyD88/NF-κB signaling pathway has been successfully used to treat renal interstitial fibrosis (RIF… Expand
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2016
2016
Beyond knockout: A novel homodimerization-targeting MyD88 inhibitor prevents and cures type 1 diabetes in NOD mice.
INTRODUCTION AND AIMS Studies have reported that myeloid differentiation factor 88 (MyD88) plays an important role in the… Expand
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2016
2016
Pharmacological inhibition of MyD88 homodimerization counteracts renal ischemia reperfusion-induced progressive renal injury in vivo and in vitro
The activation of innate immunity via myeloid differentiation factor 88 (MyD88) contributes to ischemia reperfusion (I/R) induced… Expand
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2016
2016
Targeting of MyD88 Homodimerization by Novel Synthetic Inhibitor TJ-M2010-5 in Preventing Colitis-Associated Colorectal Cancer.
BACKGROUND The TLR/MyD88 signaling pathway is an important driver of inflammation and cancer and is a possible target for… Expand
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2013
2013
Who’s My Real Daddy? Reducing the Prevalence of False Paternity in Texas
False paternity occurs when a man is incorrectly presumed, acknowledged, or adjudicated to be the father of a child even though… Expand
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2013
2013
Dendritic cells play an essential role in transplantation responses via myeloid differentiation factor 88 signaling.
BACKGROUND DCs (dendritic cells), play an important role in allo-recognition, but there is no direct evidence that DCs trigger… Expand
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2011
2011
Claim for patient fall after delivery was a medical malpractice claim. Martins v. Williamson Medical Center, No. M2010-00258-COA-R3-CV (Tenn. Ct. App. November 22, 2010).
 
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1985
1985
Bioluminescence screening for bacteriuria.
A rapid screening test (45 min) for bacteriuria was evaluated in 1,000 clinical urine specimens. The test procedure is based upon… Expand
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