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TJ-M2010-5

National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Short-term use of MyD88 inhibitor TJ-M2010-5 prevents d-galactosamine/lipopolysaccharide-induced acute liver injury in mice.
Excessive activation of the TLR/MyD88 signaling pathway contributes to several inflammation-related diseases. Previously, our… Expand
2019
2019
Modulating the conformation of the TIR domain by a neoteric MyD88 inhibitor leads to the separation of GVHD from GVT
Abstract Graft-versus-host disease (GVHD) remains the least curable complication after allogeneic bone marrow transplantation… Expand
2018
2018
A Novel Inhibitor of Homodimerization Targeting MyD88 Ameliorates Renal Interstitial Fibrosis by Counteracting TGF-β1-Induced EMT in Vivo and in Vitro
Background/Aims: The TLR/MyD88/NF-κB signaling pathway has been successfully used to treat renal interstitial fibrosis (RIF… Expand
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2016
2016
Pharmacological inhibition of MyD88 homodimerization counteracts renal ischemia reperfusion-induced progressive renal injury in vivo and in vitro
The activation of innate immunity via myeloid differentiation factor 88 (MyD88) contributes to ischemia reperfusion (I/R) induced… Expand
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2016
2016
Beyond knockout: A novel homodimerization-targeting MyD88 inhibitor prevents and cures type 1 diabetes in NOD mice.
INTRODUCTION AND AIMS Studies have reported that myeloid differentiation factor 88 (MyD88) plays an important role in the… Expand
2016
2016
Targeting of MyD88 Homodimerization by Novel Synthetic Inhibitor TJ-M2010-5 in Preventing Colitis-Associated Colorectal Cancer.
BACKGROUND The TLR/MyD88 signaling pathway is an important driver of inflammation and cancer and is a possible target for… Expand
2013
2013
Who’s My Real Daddy? Reducing the Prevalence of False Paternity in Texas
False paternity occurs when a man is incorrectly presumed, acknowledged, or adjudicated to be the father of a child even though… Expand
2013
2013
Dendritic cells play an essential role in transplantation responses via myeloid differentiation factor 88 signaling.
BACKGROUND DCs (dendritic cells), play an important role in allo-recognition, but there is no direct evidence that DCs trigger… Expand
2011
2011
Claim for patient fall after delivery was a medical malpractice claim. Martins v. Williamson Medical Center, No. M2010-00258-COA-R3-CV (Tenn. Ct. App. November 22, 2010).
1985
1985
Bioluminescence screening for bacteriuria.
A rapid screening test (45 min) for bacteriuria was evaluated in 1,000 clinical urine specimens. The test procedure is based upon… Expand
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