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TGN-1412 monoclonal antibody

Known as: TGN 1412, monoclonal antibody TGN1412, TAB08 
 
National Institutes of Health

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Highly Cited
2013
Highly Cited
2013
The failure of regulatory science to keep pace with and support the development of new biological medicines was very publically… Expand
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Review
2012
Review
2012
The development of the anti-CTLA-4 antibody (ipilimumab; marketed as Yervoy) immune regulatory therapy was based on the premise… Expand
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2011
2011
In this article, we further the study of higher K-theory of dg categories via universal invariants, initiated by the second named… Expand
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2011
2011
The failure of preclinical testing to predict the severity of the cytokine storm experienced by the recipients of the… Expand
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Highly Cited
2010
Highly Cited
2010
BACKGROUND AND PURPOSE In 2006, a life-threatening 'cytokine storm', not predicted by pre-clinical safety testing, rapidly… Expand
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Highly Cited
2010
Highly Cited
2010
TGN1412 is a "superagonistic" CD28 monoclonal antibody (IgG4) that caused serious adverse events at its first time in human… Expand
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Highly Cited
2007
Highly Cited
2007
The CD28-specific mAb TGN1412 rapidly caused a life-threatening “cytokine storm” in all six healthy volunteers in the Phase I… Expand
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Highly Cited
2006
Highly Cited
2006
Six healthy young male volunteers at a contract research organization were enrolled in the first phase 1 clinical trial of… Expand
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2006
2006
 
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2006
2006
DRUG TRIALSCAMBRIDGE, U.K.-- On 13 March, six healthy volunteers in a clinical trial were injected with a "superagonist," a drug… Expand
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