TGN-1412 monoclonal antibody

Known as: TGN 1412, monoclonal antibody TGN1412, TAB08 
 

Topic mentions per year

Topic mentions per year

2006-2016
05101520062016

Papers overview

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2012
2012
The life-threatening cytokine-release syndrome suffered by six volunteers in a Phase I clinical trial following administration of… (More)
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2011
2011
Human volunteers receiving TGN1412, a humanized CD28-specific monoclonal antibody, experienced a life-threatening cytokine… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND AND PURPOSE In 2006, a life-threatening 'cytokine storm', not predicted by pre-clinical safety testing, rapidly… (More)
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2010
2010
TGN1412 is a "superagonistic" CD28 monoclonal antibody (IgG4) that caused serious adverse events at its first time in human… (More)
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Highly Cited
2009
Highly Cited
2009
Two humanized IgG4 antibodies, natalizumab and gemtuzumab, are approved for human use, and several others, like TGN1412, are or… (More)
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2008
2008
Superagonistic CD28 antibodies (CD28SAs) activate T lymphocytes without concomitant perturbation of the TCR/CD3-complex. In… (More)
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2008
2008
In 2006, a clinical trial with the CD28 superagonistic antibody TGN1412 in London turned into a catastrophe. Studies are… (More)
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2008
2008
Administration of the CD28 superagonistic antibody JJ316 is an efficient means to treat autoimmune diseases in rats, but the… (More)
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Highly Cited
2007
Highly Cited
2007
The CD28-specific mAb TGN1412 rapidly caused a life-threatening "cytokine storm" in all six healthy volunteers in the Phase I… (More)
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Highly Cited
2006
Highly Cited
2006
Six healthy young male volunteers at a contract research organization were enrolled in the first phase 1 clinical trial of… (More)
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