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TGN-1412 monoclonal antibody

Known as: TGN 1412, monoclonal antibody TGN1412, TAB08 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Antibodies, Monoclonal, Humanized

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Revisiting CD28 Superagonist TGN1412 as Potential Therapeutic for Pediatric B Cell Leukemia: A Review
Pediatric acute lymphoblastic leukemia (ALL) represents the most common pediatric cancer diagnosis, with numbers rising gradually… 
2015
2015
Experimental drug that injured UK volunteers resumes in human trials
A phase II trial of an experimental drug that made headlines nine years ago when it caused horrific injuries to volunteers in a… 
2014
2014
Failure to upregulate cell surface PD-1 is associated with dysregulated stimulation of T cells by TGN1412-like CD28 superagonist
The CD28 superagonist (CD28SA) TGN1412 was administered to humans as an agent that can selectively activate and expand regulatory… 
2008
2008
The calm after the cytokine storm: lessons from the TGN1412 trial
In March 2006, a phase I study of the superagonistic anti-CD28 antibody TGN1412 caused a massive cytokine storm and multiorgan… 
2007
2007
Nach dem TGN1412-Zwischenfall
ZusammenfassungDer Einsatz monoklonaler Antikörper hat auf vielen klinischen Gebieten zu neuen therapeutischen Möglichkeiten gef… 
Highly Cited
2006
Highly Cited
2006
Injury to research volunteers--the clinical-research nightmare.
In March, after receiving injections of TGN1412, six volunteers became desperately ill, had multiple-organ failure, and were… 
2006
2006
Further lessons from the TGN1412 tragedy
New guidelines call for a change in the culture of research 
Review
2006
Review
2006
The strange case of TGN1412
A current focus of cancer research is the development of immunostimulatory therapeutic antibodies, based on the notion that… 
2006
2006
An Update on TGN1412
In the last issue of ATLA, we assessed whether the existing methods for assessing the safety and efficacy of new candidate… 
2006
2006
Will volunteers still want to take part in research after the TGN1412 trial
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