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TGN-1412 monoclonal antibody
Known as:
TGN 1412
, monoclonal antibody TGN1412
, TAB08
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Topic mentions per year
Topic mentions per year
2006-2016
0
5
10
15
2006
2016
Related topics
Related topics
1 relation
Broader (1)
Antibodies, Monoclonal, Humanized
Related mentions per year
Related mentions per year
1990-2018
1990
2000
2010
2020
TGN-1412 monoclonal antibody
Antibodies, Monoclonal, Humanized
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
The storm has cleared: lessons from the CD28 superagonist TGN1412 trial
Thomas Hünig
Nature Reviews Immunology
2012
The life-threatening cytokine-release syndrome suffered by six volunteers in a Phase I clinical trial following administration of…Â
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2011
2011
Preculture of PBMCs at high cell density increases sensitivity of T-cell responses, revealing cytokine release by CD28 superagonist TGN1412.
Paula S Römer
,
Susanne Berr
,
+5 authors
Thomas Hünig
Blood
2011
Human volunteers receiving TGN1412, a humanized CD28-specific monoclonal antibody, experienced a life-threatening cytokine…Â
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Highly Cited
2010
Highly Cited
2010
Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells.
D. M. Eastwood
,
Lisa Findlay
,
+6 authors
R. F. Stebbings
British journal of pharmacology
2010
BACKGROUND AND PURPOSE In 2006, a life-threatening 'cytokine storm', not predicted by pre-clinical safety testing, rapidly…Â
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2010
2010
Improved in vitro methods to predict the in vivo toxicity in man of therapeutic monoclonal antibodies including TGN1412.
Lucy Findlay
,
David S. Eastwood
,
+6 authors
Stephen J. Poole
Journal of immunological methods
2010
TGN1412 is a "superagonistic" CD28 monoclonal antibody (IgG4) that caused serious adverse events at its first time in human…Â
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Highly Cited
2009
Highly Cited
2009
Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo
Aran F Labrijn
,
Antonio Ortiz Buijsse
,
+9 authors
Paul W H I Parren
Nature Biotechnology
2009
Two humanized IgG4 antibodies, natalizumab and gemtuzumab, are approved for human use, and several others, like TGN1412, are or…Â
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2008
2008
Signaling Signatures and Functional Properties of Anti-Human CD28 Superagonistic Antibodies
Zoe Waibler
,
Linda Y. Sender
,
+6 authors
Burkhart Schraven
PloS one
2008
Superagonistic CD28 antibodies (CD28SAs) activate T lymphocytes without concomitant perturbation of the TCR/CD3-complex. In…Â
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2008
2008
CD28 superagonists: what makes the difference in humans?
Burkhart Schraven
,
Ulrich Kalinke
Immunity
2008
In 2006, a clinical trial with the CD28 superagonistic antibody TGN1412 in London turned into a catastrophe. Studies are…Â
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2008
2008
A CD28 superagonistic antibody elicits 2 functionally distinct waves of T cell activation in rats.
Nora Müller
,
Jens van den Brandt
,
+4 authors
Holger M. Reichardt
The Journal of clinical investigation
2008
Administration of the CD28 superagonistic antibody JJ316 is an efficient means to treat autoimmune diseases in rats, but the…Â
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Highly Cited
2007
Highly Cited
2007
"Cytokine storm" in the phase I trial of monoclonal antibody TGN1412: better understanding the causes to improve preclinical testing of immunotherapeutics.
Richard Stebbings
,
Lucy Findlay
,
+17 authors
Stephen J. Poole
Journal of immunology
2007
The CD28-specific mAb TGN1412 rapidly caused a life-threatening "cytokine storm" in all six healthy volunteers in the Phase I…Â
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Highly Cited
2006
Highly Cited
2006
Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412.
Ganesh Suntharalingam
,
Meghan Rose Perry
,
+4 authors
Nicki Panoskaltsis
The New England journal of medicine
2006
Six healthy young male volunteers at a contract research organization were enrolled in the first phase 1 clinical trial of…Â
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