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TGFBR2 protein, human

Known as: TGFR-2, TGF B Receptor, Transforming Growth Factor Beta Receptor 
TGF-beta receptor type-2 (567 aa, ~65 kDa) is encoded by the human TGFBR2 gene. This protein plays a role in both serine/threonine phosphorylation… 
National Institutes of Health

Related topics

Related topics

26 relations
ALK PathwayCTCF PathwayCell ProliferationEndoglin, human

Broader (3)

Receptor Serine/Threonine KinaseTransforming Growth Factor beta Receptorstransforming growth factor-beta type II receptor

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Functional characterization of the rice SPX-MFS family reveals a key role of OsSPX-MFS1 in controlling phosphate homeostasis in leaves.
• Proteins possessing the SPX domain are found in several proteins involved in inorganic phosphate (Pi) transport and signalling… 
Highly Cited
2011
Highly Cited
2011
Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma.
Pancreatic ductal adenocarcinoma (PDAC), one of the most lethal neoplasms, is characterized by an expanded stroma with marked… 
Highly Cited
2010
Highly Cited
2010
Complex regulation of two target genes encoding SPX-MFS proteins by rice miR827 in response to phosphate starvation.
Here we report on the characterization of rice osa-miR827 and its two target genes, OsSPX-MFS1 and OsSPX-MFS2, which encode SPX… 
Highly Cited
2008
Highly Cited
2008
LY2109761, a novel transforming growth factor β receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis
Most pancreatic cancer patients present with inoperable disease or develop metastases after surgery. Conventional therapies are… 
Highly Cited
2006
Highly Cited
2006
Epithelial and ectomesenchymal role of the type I TGF-beta receptor ALK5 during facial morphogenesis and palatal fusion.
Highly Cited
2005
Highly Cited
2005
Type I Transforming Growth Factor β Receptor Binds to and Activates Phosphatidylinositol 3-Kinase*
We have examined the interaction of transforming growth factor (TGF)β receptors with phosphatidylinositol 3-(PI3) kinase in… 
Highly Cited
2003
Highly Cited
2003
Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defects
Cleft palate and skull malformations represent some of the most frequent congenital birth defects in the human population… 
Highly Cited
2002
Highly Cited
2002
Internalization-Dependent and -Independent Requirements for Transforming Growth Factor β Receptor Signaling via the Smad Pathway
ABSTRACT Members of the transforming growth factor β (TGF-β) family of proteins signal through cell surface transmembrane serine… 
Highly Cited
1997
Highly Cited
1997
FKBP12 Binds the Inositol 1,4,5-Trisphosphate Receptor at Leucine-Proline (1400–1401) and Anchors Calcineurin to this FK506-like Domain*
The immunophilin FKBP12 is one of the most abundant and conserved proteins in biology. It is the primary receptor for the… 
Highly Cited
1993
Highly Cited
1993
Enhanced expression of the type II transforming growth factor beta receptor in human pancreatic cancer cells without alteration of type III receptor expression.
We have recently found that human pancreatic adenocarcinomas exhibit strong immunostaining for the three mammalian transforming… 
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