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TFEB protein, human

Known as: Transcription Factor EB, bHLHe35, transcription factor EB, human 
Transcription factor EB (476 aa, ~53 kDa) is encoded by the human TFEB gene. This protein plays a role in transcriptional regulation.
National Institutes of Health

Related topics

Related topics

10 relations

Broader (1)

Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
DNA-Binding ProteinsGenes, RegulatorLeucine ZippersTFEB gene

Papers overview

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Highly Cited
2017
Highly Cited
2017
Multistep regulation of TFEB by MTORC1
ABSTRACT The master regulator of lysosome biogenesis, TFEB, is regulated by MTORC1 through phosphorylation at S211, and a S211A… 
Highly Cited
2017
Highly Cited
2017
Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan
Drugs that mirror the cellular effects of starvation mimics are considered promising therapeutics for common metabolic disorders… 
Highly Cited
2017
Highly Cited
2017
TFEB inhibits endothelial cell inflammation and reduces atherosclerosis
TFEB suppresses oxidative stress and inflammation in endothelial cells to decrease atherosclerosis. Protected from… 
Highly Cited
2016
Highly Cited
2016
Loss of C9orf72 Enhances Autophagic Activity via Deregulated mTOR and TFEB Signaling
The most common cause of the neurodegenerative diseases amyotrophic lateral sclerosis and frontotemporal dementia is a… 
Highly Cited
2015
Highly Cited
2015
Mitochondrial Quality Control via the PGC1α-TFEB Signaling Pathway Is Compromised by Parkin Q311X Mutation But Independently Restored by Rapamycin
Following its activation by PINK1, parkin is recruited to depolarized mitochondria where it ubiquitinates outer mitochondrial… 
Review
2015
Review
2015
Early etiology of Alzheimer’s disease: tipping the balance toward autophagy or endosomal dysfunction?
Alzheimer’s disease (AD) is the most common form of dementia in the elderly. This brain neuropathology is characterized by a… 
Highly Cited
2014
Highly Cited
2014
Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance
Multidrug resistance (MDR) is a primary hindrance to curative cancer chemotherapy. In this respect, lysosomes were suggested to… 
Highly Cited
2012
Highly Cited
2012
Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes
The sensing of viral nucleic acids by the innate immune system triggers the production of type I interferons, which activates… 
Review
2008
Review
2008
Renal Translocation Carcinomas: Clinicopathologic, Immunohistochemical, and Gene Expression Profiling Analysis of 31 Cases With a Review of the Literature
We report clinicopathologic features of a large series of renal translocation carcinomas from a multicentric study. Diagnosis was… 
Highly Cited
2003
Highly Cited
2003
Cloning of an Alpha-TFEB fusion in renal tumors harboring the t(6;11)(p21;q13) chromosome translocation
MITF, TFE3, TFEB, and TFEC comprise a transcription factor family (MiT) that regulates key developmental pathways in several cell… 
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