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TERT wt Allele

Known as: Telomerase Reverse Transcriptase wt Allele, EST2, TCS1 
Human TERT wild-type allele is located in the vicinity of 5p15.33 and is approximately 42 kb in length. This allele, which encodes telomerase reverse… 
National Institutes of Health

Related topics

Related topics

8 relations
5p15.33Cell Cycle ControlNeuroblastomaPrognostic Factors

Broader (1)

TERT gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Regeneration and reprogramming compared
BackgroundDedifferentiation occurs naturally in mature cell types during epimorphic regeneration in fish and some amphibians… 
Highly Cited
2005
Highly Cited
2005
Survivin enhances telomerase activity via up-regulation of specificity protein 1- and c-Myc-mediated human telomerase reverse transcriptase gene transcription.
Highly Cited
2004
Highly Cited
2004
Immunization of Patients with the hTERT:540-548 Peptide Induces Peptide-Reactive T Lymphocytes That Do Not Recognize Tumors Endogenously Expressing Telomerase
Purpose: Telomerase is an attractive target antigen for cancer immunotherapies because it is expressed in >85% of human tumors… 
Highly Cited
2003
Highly Cited
2003
Selective ablation of human cancer cells by telomerase-specific adenoviral suicide gene therapy vectors expressing bacterial nitroreductase
Reactivation of telomerase maintains telomere function and is considered critical to immortalization in most human cancer cells… 
Highly Cited
2001
Highly Cited
2001
Ribozyme cleavage of telomerase mRNA sensitizes breast epithelial cells to inhibitors of topoisomerase.
Telomerase activity is necessary and sufficient for immortality in many cells and hence represents a prime target for antitumor… 
Highly Cited
2001
Highly Cited
2001
Lack of tumor recognition by hTERT peptide 540–548‐specific CD8+ T cells from melanoma patients reveals inefficient antigen processing
Telomerase is a ribonucleoprotein complex responsible for the maintenance of the length of the telomeres during cell division… 
Highly Cited
2001
Highly Cited
2001
BJ fibroblasts display high antioxidant capacity and slow telomere shortening independent of hTERT transfection.
Highly Cited
2000
Highly Cited
2000
A novel telomerase-specific gene therapy: gene transfer of caspase-8 utilizing the human telomerase catalytic subunit gene promoter.
Apoptosis is a genetically encoded cell death process and is a pathway that may be disrupted in tumor cells. Therefore, therapies… 
Highly Cited
2000
Highly Cited
2000
Interferon alpha down-regulates telomerase reverse transcriptase and telomerase activity in human malignant and nonmalignant hematopoietic cells.
Recently, the derepressed expression of the catalytic subunit of telomerase, human telomerase reverse transcriptase (hTERT), the… 
Highly Cited
1999
Highly Cited
1999
In vivo and in vitro analyses of Myc for differential promoter activities of the human telomerase (hTERT) gene in normal and tumor cells.
Induction of the catalytic subunit of human telomerase, hTERT, plays a critical role in the activation of telomerase during… 
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